Therapeutic Action
Antimalarial
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Drug reference
Antimalarial
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Treatment of uncomplicated falciparum malaria Treatment of uncomplicated malaria due to other Plasmodium species, when chloroquine cannot be used Completion treatment following parenteral therapy for severe malaria
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Do not administer in the event of previous severe adverse reaction to treatment with amodiaquine (e.g. hypersensitivity reaction, hepatitis, leucopenia, agranulocytosis). Do not administer to patients taking efavirenz. Avoid combination with drugs that prolong QT interval: amiodarone, other antimalarials, antipsychotics, fluconazole, fluoroquinolones, hydroxyzine, macrolides, ondansetron, etc. May cause: gastrointestinal disturbances, pruritus, somnolence or insomnia, cough. If the patient vomits within 30 minutes after administration, re-administer the full dose. If the patient vomits between 30 minutes and 1 hour after administration, re-administer half of the dose. Pregnancy: no contra-indication Breast-feeding: no contra-indication
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Co-formulated tablets of artesunate (AS)/amodiaquine (AQ), in blister packs, for a complete treatment for one individual There are 4 different blister packs corresponding to 4 different categories of weight: 25 mg AS/67.5 mg AQ base tablet blister pack of 3 tablets 50 mg AS/135 mg AQ base tablet blister pack of 3 tablets 100 mg AS/270 mg AQ base tablet blister pack of 3 tablets 100 mg AS/270 mg AQ base tablet blister pack of 6 tablets
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Tablets are to be taken once daily for 3 days. Weight Tablets D1 D2 D3 4.5 to < 9 kg 25 mg AS/67.5 mg AQ base 1 tab 1 tab 1 tab 9 to < 18 kg 50 mg AS/135 mg AQ base 1 tab 1 tab 1 tab 100 mg AS/270 mg AQ base 18 to < 36 kg 1 tab 1 tab 1 tab blister pack of 3 tab 100 mg AS/270 mg AQ base ≥ 36 kg 2 tab 2 tab 2 tab blister pack of 6 tab
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For patients unable to swallow the tablets (e.g. young children), the tablets can be dispersed by gentle agitation for approximately one minute in a small amount of water. After administration, give children some sugar or sugared water to cover amodiaquine’s bitter taste.
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- - Below 30 °C Leave tablets in blisters until use. Once a tablet is removed from its blister, it must be administered immediately.
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