Therapeutic Action
Antimalarial
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Drug reference
Antimalarial
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Treatment of malaria due to: chloroquine-sensitive P. vivax P. ovale, P. malariae and P. knowlesi
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Do not administer to patients with retinopathy. May cause: gastrointestinal disturbances, headache, transitory pruritus (lasting 72 hours), allergic reactions (urticaria, angioedema), visual disturbances. If the patient vomits within 30 minutes after administration: re-administer the full dose. If the patient vomits between 30 minutes and 1 hour after administration, re-administer half of the dose. There is a narrow margin between the therapeutic and toxic dose. Doses of 20 mg base/kg in children and 2 g base in adults are considered toxic. Avoid combination with drugs that prolong QT interval: amiodarone, other antimalarials, antipsychotics, fluconazole, fluoroquinolones, hydroxyzine, macrolides, ondansetron, etc. Do not administer simultaneously with antacids (aluminium/magnesium hydroxide, etc.) or calcium carbonate: administer 2 hours apart. Pregnancy: no contra-indication Breast-feeding: no contra-indication
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155 mg chloroquine base tablet The dose written on the labels is sometimes in chloroquine salt and sometimes in chloroquine base which leads to frequent confusion. WHO recommends prescriptions and labels in chloroquine base. 155 mg base = approx. 200 mg sulfate = approx. 250 mg phosphate or diphosphate.
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Child and adult: Day 1: 10 mg base/kg Day 2: 10 mg base/kg Day 3: 5 mg base/kg
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Also comes in 100 mg chloroquine base tablet and 50 mg chloroquine base/5 ml syrup.
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– Below 25 °C
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