Names and pronunciation
(kol′la-je-nase) Xiaflex
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Drug reference
(kol′la-je-nase) Xiaflex
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Func. class.: Enzyme
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USES: Treatment of adults with Dupuy- tren’s contracture with a palpable cord; treatment of adult men with Peyronie’s dis- ease with a palpable plaque/curvature deformity of at least 30 degrees
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CONTRAINDICATIONS: Hyper- sensitivity, pregnancy, breastfeeding
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DOSAGE AND ROUTES Dupuytren’s contracture Adult: Intralesional: Inject 0.58 mg per cord affecting a metacarpophalangeal (MP) joint or a proximal interphalangeal (PIP) joint. If contracture persists, finger extension procedure should be per- formed 24 to 72 hr following injection Peyronie’s disease Adult male: Intralesional Inject 0.58 mg into a Peyronie’s plaque; repeat 1 to 3 days later. Perform a penile modeling procedure 1-3 days after second injection. Use a second treatment cycle (two 0.58- mg injections and a penile modeling pro- cedure) in 6 wk if needed (max 4 cycles)
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Available forms: Capsules 25, 50, 75 mg
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