Therapeutic Action
Sulfonylurea antidiabetic
PDF page 153
Loading InternPractice…
Drug reference
Sulfonylurea antidiabetic
PDF page 153
Second-line treatment of type 2 diabetes, in patients under 60 years: as monotherapy, when metformin is not tolerated or contra-indicated in combination with metformin, when glycaemic control is inadequate with metformin alone
PDF page 153
Do not administer in the event of: allergy to sulfonamides; type 1 diabetes, juvenile diabetes, ketoacidosis; severe renal or hepatic impairment. May cause: hypoglycaemia, especially in patients over 60 years; gastrointestinal disturbances, weight gain; rarely, allergic reactions. Monitor combination with: diuretics, angiotensin-converting enzyme inhibitors, non-steroidal anti-inflammatory drugs, azole antifungals (fluconazole, miconazole), ciprofloxacin, erythromycin, co-trimoxazole (enhanced hypoglycaemic effect); rifampicin (decreased hypoglycaemic effect); drugs increasing blood glucose levels: corticosteroids, hydrochlorothiazide, salbutamol, chlorpromazine. Avoid combination with alcohol (antabuse reaction and risk of hypoglycaemia). Pregnancy: avoid. Insulin is the drug of choice for the treatment of type 2 diabetes in pregnant women (improved glycaemic control; reduced risk of foetal anomalies and neonatal complications). Breast-feeding: CONTRA-INDICATED
PDF pages 153, 154
5 mg scored tablet
PDF page 153
Adult: Week 1: 2.5 mg once daily in the morning Week 2: 5 mg once daily in the morning Increase if necessary in increments of 2.5 mg weekly, according to blood glucose levels. The usual dose is 5 mg 2 times daily (max. 15 mg daily).
PDF page 153
Take with meals. For doses greater than 5 mg/day, divide the daily dose into 2 doses.
PDF page 154
- Below 25 °C
PDF page 154