Therapeutic Action
Sulfonylurea antidiabetic
PDF page 155
Loading InternPractice…
Drug reference
Sulfonylurea antidiabetic
PDF page 155
Second-line treatment of type 2 diabetes, in patients over 60 years: as monotherapy, when metformin is not tolerated or contra-indicated in combination with metformin, when glycaemic control is inadequate with metformin alone
PDF page 155
Do not administer in the event of: allergy to sulfonamides; type 1 diabetes, juvenile diabetes, ketoacidosis; severe renal or hepatic impairment. May cause: hypoglycaemia, gastrointestinal disturbances, weight gain; rarely, allergic reactions. Monitor combination with: diuretics, angiotensin-converting enzyme inhibitors, non-steroidal anti-inflammatories, azole antifungals (fluconazole, miconazole), ciprofloxacin, erythromycin, co-trimoxazole (enhanced hypoglycaemic effect); rifampicin (decreased hypoglycaemic effect); drugs increasing blood glucose levels: corticosteroids, hydrochlorothiazide, salbutamol, chlorpromazine. Avoid combination with alcohol (risk of hypoglycaemia). Pregnancy: avoid. Insulin is the drug of choice for the treatment of type 2 diabetes in pregnant women (improved glycaemic control; reduced risk of foetal anomalies and neonatal complications). Breast-feeding: CONTRA-INDICATED
PDF pages 155, 156
80 mg scored tablet
PDF page 155
Adult: Weeks 1 and 2: 40 mg once daily in the morning Increase if necessary in increments of 40 mg every 2 weeks, according to blood glucose levels (Weeks 3 and 4: 80 mg once daily in the morning). The usual dose is 80 to 160 mg daily (max. 240 mg daily).
PDF page 155
Take with meals (reduced risk of gastrointestinal disturbances). For doses greater than 80 mg daily, divide the daily dose into 2 doses. Also comes in 30 and 60 mg modified release tablets.
PDF page 156
- Below 25 °C
PDF page 156