Names and pronunciation
(hye-droks-ee-proe-jes′te-rone cap′ro-ate) Makena
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Drug reference
(hye-droks-ee-proe-jes′te-rone cap′ro-ate) Makena
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Func. class.: Hormone, progesterone
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USES: To reduce the risk of preterm birth
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CONTRAINDICATIONS Hyper- sensitivity to hydroxyprogesterone capro- ate or any component; current or history of thrombosis or thromboembolic disor- ders; breast cancer or other hormone- sensitive cancer; undiagnosed abnormal vaginal bleeding unrelated to pregnancy; cholestatic jaundice of pregnancy; liver tumors (benign or malignant) or active liver disease; missed abortion; uncon- trolled hypertension; as a diagnostic test for pregnancy
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DOSAGE AND ROUTES Adult female: IM (vial): 250 mg q7days SUBCUT 275 mg q7days; treatment may begin between 16 wk, 0 days and 20 wk, 6 days of gestation. Continue weekly administration until 37 wk (through 36 wk, 6 days) gestation or until delivery, whichever comes first HIGH ALERT
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