Names and pronunciation
(ir-be-sar′tan/hye-droe-klor-oh- thye′a-zide) Avalide
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Drug reference
(ir-be-sar′tan/hye-droe-klor-oh- thye′a-zide) Avalide
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Func. class.: Angiotensin II receptor blocker, antihypertensive, diuretic, thiazide
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USES: Hypertension
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CONTRAINDICATIONS Hypersensitivity to irbesartan, hydro- chlorothiazide, sulfonamide-derived drugs; concomitant use with aliskiren in those with diabetes mellitus; anuria
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Black Box Warning: Pregnancy
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DOSAGE AND ROUTES Adult PO Initial therapy: Irbesartan 150 mg/hydrochlorothiazide 12.5 mg once daily. If initial response is inade- quate, may titrate dose after 1 to 2 wk (max daily dose: irbesartan 300 mg/ hydrochlorothiazide 25 mg) HIGH ALERT
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