Names and pronunciation
(eye-rye-no-tee′-kan lye-po-so′m) Onivyde
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Drug reference
(eye-rye-no-tee′-kan lye-po-so′m) Onivyde
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Func. class.: Antineoplastic agent, camptothecin, topoisomerase I inhibitor
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USES: Pancreatic adenocarcinoma, metastatic
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CONTRAINDICATIONS Severe hypersensitivity to irinotecan lipo- some, irinotecan hydrochloride, or any component
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Black Box Warning: Diarrhea, GI ob- struction, neutropenia
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DOSAGE AND ROUTES Pancreatic adenocarcinoma, metastatic Adult: IV: 70 mg/m2 once every 2 wk (in combination with fluorouracil and leu- covorin); reduce initial starting dose to 50 mg/m2 in patients known to be homo- zygous for the UGT1A1*28 allele; the dose may be increased to 70 mg/m2 as tolerated in subsequent cycles
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Available forms: Injection 43 mg/10 mL
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