Therapeutic Action
Antiparkinson drug
PDF page 193
Loading InternPractice…
Drug reference
Antiparkinson drug
PDF page 193
Parkinson’s disease and extrapyramidal disorders except those induced by antipsychotics
PDF page 193
Do not administer in case of severe psychosis, confusion, closed-angle glaucoma, recent myocardial infarction, malignant melanoma. May cause: early in treatment, when dose is not adjusted : anorexia, vomiting, orthostatic hypotension, frequent delayed adverse effects, signs of excessive dosage, mainly: dyskinesia, tremor; mental disorders more frequent in older patients: confusional state or depression with or without suicidal tendencies; later in treatment : fluctuation of the effect during the day (in this event, daily dosage may be divided into smaller doses and taken more frequently); or reduction of the effect (progression of the disease). Administer with caution in mental disorders, cardiac disease, gastroduodenal ulcer. Do not administer simultaneously with MAOI antidepressants, antipsychotics, reserpine. Pregnancy: CONTRA-INDICATED Breast-feeding: CONTRA-INDICATED
PDF pages 193, 194
100 mg levodopa + 10 mg carbidopa tablet 250 mg levodopa + 25 mg carbidopa tablet
PDF page 193
Doses are expressed as levodopa: Adult: Initial dose: 50 to 125 mg 3 times daily, immediately after meals. Increase by 50 to 125 mg every day or every 2 days until the optimal dose for the individual patient is reached. Maintenance dose usually: 250 to 500 mg 3 times daily, immediately after meals (max. 2 g daily) Reduce dosage in older patients.
PDF page 193
According to clinical response
PDF page 193
Tablet must be swallowed whole. Do not chew or dissolve.
PDF page 194
– Below 25 °C
PDF page 194