Names and pronunciation
(lin-a-glip′tin/met-for′min) Jentadueto, Jentadueto XR
PDF page 790
Loading InternPractice…
Drug reference
(lin-a-glip′tin/met-for′min) Jentadueto, Jentadueto XR
PDF page 790
Func. class.: Antidiabetic agent, biguanide/dipeptidyl peptidase 4 (DPP- 4) inhibitor
PDF page 790
USES: An adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus
PDF page 790
CONTRAINDICATIONS Hypersensitivity to linagliptin, metformin, or any component; severe renal impair- ment (eGFR <30 mL/min/1.73 m2); metabolic acidosis, diabetic ketoacidosis
PDF page 790
Black Box Warning: Fatal lactic acidosis
PDF page 790
DOSAGE AND ROUTES Adult: PO (Immediate release): to 1 g bid; (extended release) linagliptin those currently on metformin: Initial: linagliptin 5 mg/day plus current daily dose of metformin; those not on met- formin: Initial: linagliptin 5 mg/metfor- min 1 g/day; conversion from IR to ER: May switch to extended-release product containing linagliptin 5 mg and current daily dose of metformin once daily
PDF page 790
Available forms: Tabs 2.5/500, 2.5/850, 2.5/1000 mg; tabs ext rel 2.5/1000, 5/1000 mg
PDF page 790