Names and pronunciation
(mes′na) Mesnex, Uromitexan
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Drug reference
(mes′na) Mesnex, Uromitexan
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Func. class.: Antidote, chemoprotec- tive agent
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USES: Prevention of ifosfamide- induced hemorrhagic cystitis M
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CONTRAINDICATIONS Hypersensitivity
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DOSAGE AND ROUTES Prevention of ifosfamide-induced hemorrhagic cystitis. Adult standard- dose ifosfamide: IV: Each mesna dose is equal to 20% of the daily ifosfamide dose given for 3 doses: With the ifosfamide dose (hour 0), hour 4, and at hour 8 after the ifosfamide dose (total daily mesna dose is 60% of the daily ifos- famide dose); PO mesna (following IV mesna; for ifosfamide doses ≤2 g/m2/ day): Mesna dose (IV) is equal to 20% of the daily ifosfamide dose at hour 0, fol- lowed by 2 mesna doses (orally), each equal to 40% of the daily ifosfamide dose given 2 and 6 hr after the ifosfamide dose (total daily mesna dose is 100% of the daily ifosfamide dose) Adult: Short infusion standard-dose ifos- famide (<2.5 g/m2/day): IV: Total mesna dose is equal to 60% of the ifosfamide dose, in 3 divided doses (each mesna dose as 20% of daily ifos- famide dose), given 15 min before the ifosfamide dose and 4 and 8 hr after each dose of ifosfamide Adult: Continuous infusion standard- dose ifosfamide (<2.5 g/m2/day): IV: Mesna dose (as a bolus) is equal to 20% of the daily ifosfamide dose, fol- lowed by a continuous infusion of mesna at 40% of the daily ifosfamide dose; continue mesna infusion for 12 to 24 hr after completion of ifosfamide infusion Prevention of cyclophosphamide- induced hemorrhagic cystitis Adults <40 yr of age: IV: Cycles 1, 2, 3, and 6 (cyclophosphamide-containing regi- men): 2.1 g/m2/day continuous infusion (mesna dose is equivalent to the daily cyclophosphamide dose) for 2 days with cyclophosphamide infusion during cycles 1, 2, 3, and 6 HIGH ALERT
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