Names and pronunciation
Nah-far′eh-lin Synarel
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Drug reference
Nah-far′eh-lin Synarel
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Func. class.: Gonadotropin-releasing hormone analogue
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USES: Central precocious puberty, endometriosis
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CONTRAINDICATIONS Hypersensitivity to gonadotropin-releasing hormone (GnRH), GnRH-agonist analogs, or any component; undiagnosed abnormal vaginal bleeding; pregnant women or those who may become pregnant; breastfeeding
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DOSAGE AND ROUTES Endometriosis: Adult female: Intranasal: 1 spray (200 mcg) into 1 nos- tril each morning and 1 spray (200 mcg) into the other nostril each evening starting between days 2 and 4 of menstrual cycle (total: 2 sprays [400 mcg] daily). If regu- lar menstruation persists after 2 mo of therapy, may increase dose to 2 sprays (400 mcg; 1 spray in each nostril) in the morning and evening (total: 4 sprays [800 mcg] daily), max 6 mo Central precocious puberty Child males (≤9 yr)/females (≤8 yr): Intranasal: 2 sprays (400 mcg) into each nostril in the morning and 2 sprays (400 mcg) into each nostril in the eve- ning
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Available forms: Nasal spray 2 mg/ mL/200 mcg/spray
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