Names and pronunciation
(peg-val′i-ase) Palynziq
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Drug reference
(peg-val′i-ase) Palynziq
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Func. class.: Phenylalanine ammonia lyase enzyme
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USES: To reduce blood phenylalanine concentrations in phenylketonuria (PKU) patients who have uncontrolled blood phenylalanine concentrations >600 micromol/L on existing management
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CONTRAINDICATIONS
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Black Box Warning: Serious hypersensi- tivity or anaphylaxis
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DOSAGE AND ROUTES Phenylketonuria (PKU) Adult: SUBCUT Induction: 2.5 mg weekly × 4 wk Titration (after 4-wk induction): 2.5 mg twice weekly × 1 wk, then 10 mg weekly for 1 wk, then 10 mg twice weekly for 1 wk, then 10 mg 4 times/wk for 1 wk, then 10 mg day × 1 wk. Additional time may be required before each dosage escalation based on patient tolerability; maintenance: 20 mg daily × ≥ 24 wk. Individualize dose to achieve blood ≤600 phenylalanine concentration micromol/L; may increase to 40 mg daily if a response (blood phenylalanine con- centration 600 micromol/L or less) has not been achieved after using 20 mg daily × 24 wk, max 60 mg/day
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Available forms: Injection 2.5, 10, 20 mg/0.5 mL single-dose syringe HIGH ALERT
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