Names and pronunciation
per-fen′a-zeen/am-i-trip′ti-leen
PDF page 1043
Loading InternPractice…
Drug reference
per-fen′a-zeen/am-i-trip′ti-leen
PDF page 1043
Func. class.: Tricyclic antidepressant/ phenothiazine
PDF page 1043
USES: Treatment of moderate-to- severe anxiety and/or agitation and depression; schizophrenia with depressive symptoms
PDF page 1043
CONTRAINDICATIONS Hypersensitivity to amitriptyline, per- phenazine, or any component, other phe- nothiazines, bone marrow depression; within 14 days of MAOIs; CNS depression (barbiturates, alcohol, opioids, analge- sics, antihistamines); during the acute recovery of MI
PDF page 1043
Black Box Warning: Dementia-related psychosis, children
PDF page 1044
DOSAGE AND ROUTES Depression/anxiety Adult: PO 1 tablet (amitriptyline 25 mg/ perphenazine 2 mg or amitriptyline 25 mg/perphenazine 4 mg) tid-qid or 1 tablet (amitriptyline 50 mg/perphenazine 4 mg) bid; max amitriptyline 200 mg/ perphenazine 16 mg; maintenance: usu- ally 1 tablet (amitriptyline 25 mg/per- phenazine 2 mg or amitriptyline 25 mg/ perphenazine 4 mg) bid-qid or 1 tablet (amitriptyline 50 mg/perphenazine 4 mg) bid Schizophrenia with depressive symptoms. Adult: PO 2 tablets (amitriptyline 25 mg/ perphenazine 4 mg) tid; may give a fourth dose at bedtime; max amitriptyline 200 mg/perphenazine 16 mg; mainte- nance: usually 1 tablet (amitriptyline 25 mg/perphenazine 2 mg or amitriptyline 25 mg/perphenazine 4 mg) bid-qid or 1 tablet (amitriptyline 50 mg/perphenazine 4 mg) bid
PDF page 1044
Available forms: Tabs 2/10, 2/25, 4/10, 4/25, 4/50 mg HIGH ALERT
PDF page 1044