Names and pronunciation
(fen-tole′a-meen) OraVerse
PDF page 1046
Loading InternPractice…
Drug reference
(fen-tole′a-meen) OraVerse
PDF page 1046
Func. class.: Antidote (extravasation), alpha1 blocker Uses: Diagnosis of pheochromocytoma via phentolamine blocking; prevention/ treatment of hypertensive episodes associated with pheochromocytoma; prevention/treatment of dermal necrosis/ sloughing after extravasation of norepinephrine; reversal of soft tissue anesthesia
PDF pages 1046, 1047
CONTRAINDICATIONS Hypersensitivity to phentolamine, any component; MI, coronary insufficiency, angina, CAD (excluding OraVerse)
PDF page 1047
DOSAGE AND ROUTES Extravasation of norepinephrine, management Adult: Local infiltration: Inject 5-10 mg (diluted in 10 mL normal saline) into extravasation area Diagnosis of pheochromocytoma (phentolamine-blocking test) Adult: IM, IV: 5 mg Perioperative hypertensive episodes associated with pheochromocytoma, prevention and management Adult: Preoperative: IM, IV: 5 mg 1-2 hr before surgery and repeat if needed; intraoperative: IV: 5 mg as needed
PDF page 1047
Available forms: Powder for injection 5 mg See Appendix B See Appendix B
PDF page 1047