Names and pronunciation
(proe-ben′e-sid/kol′chi-seen)
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Drug reference
(proe-ben′e-sid/kol′chi-seen)
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Func. class.: Antiinflammatory agent, antigout, uricosuric
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USES: Treatment of chronic gouty arthritis with frequent, recurrent acute attacks of gout
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CONTRAINDICATIONS Hypersensitivity to colchicine, proben- ecid, or any component; child <2 yr; aspirin usage; blood dyscrasias; uric acid kidney stones; initiation during an acute gout attack; concomitant use of a P-glycoprotein (P-gp) or strong CYP3A4 inhibitor in renal/hepatic disease
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DOSAGE AND ROUTES Gouty arthritis Adult: PO Colchicine 0.5 mg/probenecid 0.5 g: 1 tablet daily × 1 week, then 1 tablet bid, max 4 tablets/day
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Available forms: Tabs 500 mg/0.5 mg HIGH ALERT
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