Names and pronunciation
(ri-me′je-pant) Nurtec ODT
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Drug reference
(ri-me′je-pant) Nurtec ODT
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Func. class.: Antimigraine agent
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Chem. class.: Calcitonin gene–related peptide receptor antagonist
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ACTION: Involved in transmission through second- and third-order neurons and pain modulation in the brainstem
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USES: Acute treatment of migraine with or without aura, migraine, prophylaxis
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CONTRAINDICATIONS: Hypersensitivity Precautions: Pregnancy, breastfeeding, hepatic/renal disease
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SIDE EFFECTS GI: Nausea INTEG: Rash, hypersensitivity RESP: Dyspnea
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INTERACTIONS Increase: Effect of CYP3A4 substrates Increase: Rimegepant effect—CYP3A4 inhibitors Decrease: Rimegepant effect—CY3A4 inducers NURSING CONSIDERATIONS
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DOSAGE AND ROUTES Migraine Adult: PO 75 mg as a single dose; max 75 mg/24 hr Migraine prophylaxis Adult: PO 75 mg every other day
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Available forms: Tablet ODT 75 mg
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Administer: • Peel foil covering blister to remove table with dry hands. Do not push tablet through the foil. • Place tablet on or under tongue, allow to dissolve • Can be swallowed without additional fluids • Store at 20°C to 25°C (68°F to 77°F)
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Assess: • Migraine: Baseline and periodically, presence of aura, nausea/vomiting • Assess for hypersensitivity, rash, dys- pnea; reaction may be delayed, discon- tinue if these occur • Avoid use in hepatic/renal disease
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Evaluate: • Therapeutic response: Resolution of migraine
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Patient and caregiver information: • Reason for product and expected result • Identify if pregnancy is planned or suspected See Appendix B
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PHARMACOKINETICS Onset ≤2 hr, peak 1.5 hr, duration 48 hr, half-life 11 hr, protein binding 96%
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