Therapeutic Action
Antimalarial
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Drug reference
Antimalarial
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Intermittent preventive treatment of malaria in pregnancy (IPTp-SP), as of the second trimester, in areas with moderate to high malaria transmission in Africa
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Do not administer to patients with allergy to sulfonamides. Do not administer to HIV-infected women taking co-trimoxazole prophylaxis. May cause: gastrointestinal disturbances, skin reactions, sometimes severe (toxic epidermal necrolysis and Stevens-Johnson syndrome); anaemia, leukopenia, agranulocytosis, thrombocytopenia, haemolytic anaemia in patients with G6PD deficiency. Do not use in combination with co-trimoxazole. Do not give folic acid on the same day SP is administered, or within 2 weeks thereafter. Pregnancy: CONTRA-INDICATED during the first trimester (risk of neural tube defects)
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Sulfadoxine 500 mg/pyrimethamine 25 mg tablet Sulfadoxine 500 mg/pyrimethamine 25 mg dispersible tablet
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3 tablets single dose for each treatment, starting as early as possible in the second trimester Each treatment should be given at least one month apart and at least 3 doses should be given during pregnancy.
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Also comes as co-packaged dispersible tablets for seasonal malaria chemoprevention in children: amodiaquine 153 mg + sulfadoxine/pyrimethamine 500 mg/25 mg and amodiaquine 76.5 mg + sulfadoxine/pyrimethamine 250 mg/12.5mg.
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– Below 25 °C
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