Therapeutic Action
Vitamin
PDF page 493
Loading InternPractice…
Drug reference
Vitamin
PDF page 493
Initial treatment of severe thiamine (vitamin B ) deficiency: severe acute forms of beriberi, 1 neurological complications of chronic alcoholism (delirium tremens, Wernicke’s encephalopathy)
PDF page 493
May cause: hypotension; anaphylactic reaction, especially when injected IV (inject very slowly over 30 minutes). Pregnancy: no contra-indication Breast-feeding: no contra-indication
PDF page 493
100 mg thiamine hydrochloride in 2 ml ampoule (50 mg/ml) for IM or very slow IV route (30 minutes)
PDF page 493
Infantile beriberi 25 mg by IV route then, 25 mg by IM route once or 2 times daily then, change to oral route (10 mg once daily) as soon as symptoms have improved. Acute beriberi 50 mg by IM route then change to oral route (50 mg 3 times daily until symptoms improve then, 10 mg once daily) or, depending on severity, 50 mg by IM route every 8 hours for a few days then change to oral route (10 mg once daily). Delirium tremens, Wernicke’s encephalopathy 100 mg by IM or IV route 3 times daily for 3 to 5 days
PDF page 493
Thiamine is also called aneurine. Injectable thiamine is not included in the WHO list of essential medicines.
PDF page 494
– Below 25 °C
PDF page 494