Therapeutic Action
Sympathomimetic
Source page 398
Loading InternPractice…
Individual generic drug information
Extracted information for EPINEPHRINE only.
Sympathomimetic
Source page 398
Severe anaphylactic reaction Acute hypotension despite fluid therapy in shock
Source page 398
Extracted information for EPINEPHRINE only.
Administer with caution to patients with hypertension, angina, ischaemic heart disease, hyperthyroidism and to older patients. May cause: arrhythmia, hypertension, agitation, headache; tissue necrosis following extravasation (use a large vein for IV administration). Pregnancy and breast-feeding: no contra-indication
Source page 399
Extracted information for EPINEPHRINE only.
1 mg in 1 ml ampoule (1 mg/ml) for IM injection only 1 mg in 1 ml ampoule (1 mg/ml) for IV injection or infusion only
Source page 398
Severe anaphylactic reaction Administer undiluted solution by IM route (anterolateral part of the thigh) using a 1 ml syringe graduated in 0.01 ml: Child under 6 months: 0.1 to 0.15 ml Child 6 months to 5 years: 0.15 ml Child 6 to 12 years: 0.3 ml Child over 12 years and adult: 0.5 ml (0.3 ml if small or prepubertal child) Repeat after 5 minutes if no or poor clinical improvement (up to a total of 3 IM injections). Acute hypotension despite fluid therapy or anaphylactic reaction unresponsive to epinephrine IM Use diluted solution in 0.9% sodium chloride (NaCl 0.9%) or 5% glucose (G5%) or Ringer lactate (RL): Child under 40 kg: add 2 ml of EPN (2 amp. of 1 mg/ml for IV route) to 38 ml of NaCl 0.9%, G5% or RL to obtain a 0.05 mg/ml (50 micrograms/ml) solution. Child 40 kg and over and adult: add 4 ml of EPN (4 amp. of 1 mg/ml for IV route) to 36 ml of NaCl 0.9%, G5% or RL to obtain a 0.1 mg/ml (100 micrograms/ml) solution. Administer by continuous IV infusion using an infusion or syringe pump: Child and adult: 0.1 microgram/kg/min, increase if necessary by 0.05 micrograms/kg/min every 10 min for the first hour, then every hour (max. 1 microgram/kg/min) Once desired response is achieved, discontinue gradually, in decrements of 0.05 micrograms/kg/min every hour. Do not discontinue abruptly. The infusion rate is calculated as follows: [desired dose (microgram/kg/min) x weight (kg) x 60 min]/concentration (microgram/ml). Example, for a child 20 kg, dose 0.1 microgram/kg/min, solution concentration 50 micrograms/ml: EPN dose (microgram/kg/min) 0.1 0.15 0.2 0.25 0.3 0.35 0.4 0.45 0.5 Infusion rate (ml/hour) 2.4 3.6 4.8 6 7.2 8.4 9.6 10.8 12
Source pages 398, 399
Extracted information for EPINEPHRINE only.
In anaphylaxis, use IV treatment only if no or poor improvement after 3 IM injections or if there is a circulatory collapse. Epinephrine can be used via nebulizer in the management of airway obstruction due to certain respiratory diseases (e.g. croup, diphtheria): 0.5 mg/kg (max. 5 mg) to be repeated every 20 minutes if necessary. Epinephrine is colourless: discard any ampoules with a pink or brownish colour. Also comes in 0.15 mg/0.3 ml and 0.3 mg/0.3 ml pre-filled auto-injector.
Source page 399
– Below 25 °C
Source page 399
Filter the extracted dose blocks for this individual drug.
0.5 ml (0.3 ml if small or prepubertal child)
Candidate age grouping · source page 398
add 4 ml of EPN (4 amp. of 1 mg/ml for IV route) to 36 ml of NaCl 0.9%, G5% or RL to obtain a 0.1 mg/ml (100 micrograms/ml) solution.
Candidate age grouping · source page 399
0.1 microgram/kg/min, increase if necessary by 0.05 micrograms/kg/min every
Candidate age grouping · source page 399