Individual generic drug information

perindopril erbumine

Reference monograph

Part of registered formulation

AMLODIPINE BESILATE + PERINDOPRIL ERBUMINE

Reference record: Perindopril erbumine
Source: BNF 80 (2020–2021)
Printed source pages: 205
Age groups indexed: 2

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Perindopril erbumine only.

Indications And Dose

Hypertension ▶BY MOUTH ▶Adult: Initially 4 mg once daily for 1 month, dose to be taken in the morning, then, adjusted according to response; maximum 8 mg per day ▶BY MOUTH ▶Elderly: Initially 2 mg once daily for 1 month, dose to be taken in the morning, then, adjusted according to response; maximum 8 mg per day Hypertension, if used in addition to diuretic, or in cardiac decompensation or volume depletion ▶BY MOUTH ▶Adult: Initially 2 mg once daily for 1 month, dose to be taken in the morning, then, adjusted according to response; maximum 8 mg per day Heart failure (adjunct) (under close medical supervision) ▶BY MOUTH ▶Adult: Initially 2 mg once daily for at least 2 weeks, dose to be taken in the morning, then increased if tolerated to 4 mg once daily Prophylaxis of cardiac events following myocardial infarction or revascularisation in stable coronary artery disease ▶BY MOUTH Cardiovascular system ▶Adult: Initially 4 mg once daily for 2 weeks, dose to be taken in the morning, then increased if tolerated to 8 mg once daily ▶Elderly: Initially 2 mg once daily for 1 week, then increased if tolerated to 4 mg once daily for 1 week, then increased if tolerated to 8 mg once daily

Source page 205

Safety

Extracted information for Perindopril erbumine only.

Interactions

→Appendix 1: ACE inhibitors

Source page 205

Side Effects

▶Common or very common Muscle cramps. visual impairment ▶Uncommon Fall. hypoglycaemia. malaise. mood altered. vasculitis ▶Rare or very rare Cholestasis

Source page 205

Breast Feeding

Not recommended; alternative treatment options, with better established safety information during breast-feeding, are available.

Source page 205

Hepatic Impairment

Perindopril is a prodrug.

Source page 205

Renal Impairment

Dose adjustments Max. initial dose 2 mg once daily if eGFR 30–60 mL/minute/1.73 m2; 2 mg once daily on alternate days if eGFR 15–30 mL/minute/1.73 m2.

Source page 205

Dose and formulations

Extracted information for Perindopril erbumine only.

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral suspension, oral solution Tablet CAUTIONARY AND ADVISORY LABELS 22 ▶Perindopril erbumine (Non-proprietary) Perindopril erbumine 2 mg Perindopril erbumine 2mg tablets | 30 tablet P £12.99 DT = £1.90 | 56 tablet P £3.34 | 60 tablet P £13.90 Perindopril erbumine 4 mg Perindopril erbumine 4mg tablets | 30 tablet P £12.99 DT = £2.33 | 56 tablet P £3.38 | 60 tablet P £27.80 Perindopril erbumine 8 mg Perindopril erbumine 8mg tablets | 30 tablet P £12.99 DT = £2.32 | 56 tablet P £3.88 | 60 tablet P £40.00 eiiii F 179

Source page 205

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

Initially 4 mg once daily for 1 month, dose to be

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 205

Adults

First line only; read the complete Indications and dose section above.

Initially 2 mg once daily for 1 month, dose to be

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 205

Adults

First line only; read the complete Indications and dose section above.

Initially 2 mg once daily for at least 2 weeks,

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 205

Adults

First line only; read the complete Indications and dose section above.

Initially 4 mg once daily for 2 weeks, dose to be

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 205

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.

Individual generic drug information

perindopril erbumine

Reference monograph

Part of registered formulation

AMLODIPINE BESILATE + PERINDOPRIL ERBUMINE

Reference record: Perindopril erbumine
Source: BNF 80 (2020–2021)
Printed source pages: 205
Age groups indexed: 2

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Perindopril erbumine only.

Indications And Dose

Source page 205

Safety

Extracted information for Perindopril erbumine only.

Interactions

→Appendix 1: ACE inhibitors

Source page 205

Side Effects

▶Common or very common Muscle cramps. visual impairment ▶Uncommon Fall. hypoglycaemia. malaise. mood altered. vasculitis ▶Rare or very rare Cholestasis

Source page 205

Breast Feeding

Not recommended; alternative treatment options, with better established safety information during breast-feeding, are available.

Source page 205

Hepatic Impairment

Perindopril is a prodrug.

Source page 205

Renal Impairment

Dose adjustments Max. initial dose 2 mg once daily if eGFR 30–60 mL/minute/1.73 m2; 2 mg once daily on alternate days if eGFR 15–30 mL/minute/1.73 m2.

Source page 205

Dose and formulations

Extracted information for Perindopril erbumine only.

Medicinal Forms

Source page 205

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

Initially 4 mg once daily for 1 month, dose to be

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 205

Adults

First line only; read the complete Indications and dose section above.

Initially 2 mg once daily for 1 month, dose to be

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 205

Adults

First line only; read the complete Indications and dose section above.

Initially 2 mg once daily for at least 2 weeks,

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 205

Adults

First line only; read the complete Indications and dose section above.

Initially 4 mg once daily for 2 weeks, dose to be

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 205

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.