Indications And Dose
Infections due to beta-lactamase-producing staphylococci including otitis externa | Adjunct in pneumonia ▶BY MOUTH ▶Child 1 month–1 year: 62.5–125 mg 4 times a day ▶Child 2–9 years: 125–250 mg 4 times a day ▶Child 10–17 years: 250–500 mg 4 times a day ▶Adult: 250–500 mg 4 times a day ▶BY INTRAMUSCULAR INJECTION ▶Adult: 250–500 mg every 6 hours ▶BY SLOW INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult: 0.25–2 g every 6 hours Impetigo ▶BY MOUTH ▶Child 1 month–1 year: 62.5–125 mg 4 times a day for 5–7 days ▶Child 2–9 years: 125–250 mg 4 times a day for 5–7 days ▶Child 10–17 years: 250–500 mg 4 times a day for 5–7 days ▶Adult: 500 mg 4 times a day for 5–7 days ▶BY INTRAMUSCULAR INJECTION ▶Adult: 250–500 mg every 6 hours ▶BY SLOW INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult: 0.25–2 g every 6 hours Cellulitis | Erysipelas ▶BY MOUTH ▶Child 1 month–1 year: 62.5–125 mg 4 times a day for 5–7 days then review ▶Child 2–9 years: 125–250 mg 4 times a day for 5–7 days then review ▶Child 10–17 years: 250–500 mg 4 times a day for 5–7 days then review ▶Adult: 0.5–1 g 4 times a day for 5–7 days then review ▶BY SLOW INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult: 1–2 g every 6 hours Mild diabetic foot infection ▶BY MOUTH ▶Adult: 0.5–1 g 4 times a day for 7 days then review Moderate diabetic foot infection | Severe diabetic foot infection ▶BY MOUTH ▶Adult: 1 g 4 times a day ▶BY SLOW INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult: 1–2 g every 6 hours Leg ulcer infection ▶BY MOUTH ▶Adult: 0.5–1 g 4 times a day for 7 days ▶BY SLOW INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult: 1–2 g every 6 hours Endocarditis (in combination with other antibacterial if necessary) ▶BY SLOW INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult (body-weight up to 85 kg): 8 g daily in 4 divided doses ▶Adult (body-weight 85 kg and above): 12 g daily in 6 divided doses Osteomyelitis ▶BY SLOW INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult: Up to 8 g daily in 3–4 divided doses Surgical prophylaxis ▶INITIALLY BY SLOW INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult: 1–2 g, to be administered up to 30 minutes before the procedure, then (by mouth or by intramuscular injection or by slow intravenous injection or by intravenous infusion) 500 mg every 6 hours if required for up to 4 further doses in high risk procedures Staphylococcal lung infection in cystic fibrosis ▶BY MOUTH ▶Child: 25 mg/kg 4 times a day (max. per dose 1 g), alternatively 100 mg/kg daily in 3 divided doses; maximum 4 g per day Prevention of Staphylococcus aureus lung infection in cystic fibrosis—primary prevention ▶BY MOUTH ▶Child 1 month–3 years: 125 mg twice daily Prevention of Staphylococcus aureus lung infection in cystic fibrosis—secondary prevention ▶BY MOUTH ▶Child: 50 mg/kg twice daily (max. per dose 1 g twice daily) l UNLICENSED USE Flucloxacillin doses in the BNF may differ from those in product literature.
Source pages 608, 609