Individual generic drug information

ampicillin

Reference monograph

Part of registered formulation

AMPICILLIN SODIUM

Reference record: Ampicillin
Source: BNF 80 (2020–2021)
Printed source pages: 603, 604
Age groups indexed: 2

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Ampicillin only.

Indications And Dose

Susceptible infections (including bronchitis, urinary-tract infections, otitis media, sinusitis, uncomplicated community-acquired pneumonia, salmonellosis) ▶BY MOUTH ▶Child 1–11 months: 125 mg 4 times a day; increased if necessary up to 30 mg/kg 4 times a day ▶Child 1–4 years: 250 mg 4 times a day; increased if necessary up to 30 mg/kg 4 times a day ▶Child 5–11 years: 500 mg 4 times a day; increased if necessary up to 30 mg/kg 4 times a day (max. per dose 1 g) ▶Child 12–17 years: 500 mg 4 times a day; increased if necessary to 1 g 4 times a day, use increased dose in severe infection ▶Adult: 0.5–1 g every 6 hours ▶BY INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult: 500 mg every 4–6 hours ▶BY INTRAMUSCULAR INJECTION ▶Adult: 500 mg every 4–6 hours Endocarditis (in combination with another antibiotic if necessary) | Listerial meningitis (in combination with another antibiotic) ▶BY INTRAVENOUS INFUSION ▶Adult: 2 g every 4 hours l UNLICENSED USE ▶In adults Ampicillin doses in BNF may differ from those in product literature.

Source page 603

Cautions

GENERAL CAUTIONS Acute lymphocytic leukaemia (increased risk of erythematous rashes). chronic lymphocytic leukaemia (increased risk of erythematous rashes). cytomegalovirus infection (increased risk of erythematous rashes). glandular fever (erythematous rashes common) SPECIFIC CAUTIONS ▶With intravenous use Accumulation of electrolytes contained in parenteral preparations can occur with high doses

Source page 603

Safety

Extracted information for Ampicillin only.

Interactions

→Appendix 1: penicillins

Source page 603

Side Effects

Colitis haemorrhagic

Source page 603

Pregnancy

Not known to be harmful.

Source page 603

Breast Feeding

Trace amounts in milk, but appropriate to use.

Source page 603

Renal Impairment

▶With intravenous use Accumulation of electrolytes contained in parenteral preparations can occur in patients with renal failure. Dose adjustments ▶In adults Reduce dose if eGFR less than 10 mL/minute/1.73 m2; rashes more common. ▶In children If estimated glomerular ﬁltration rate less than 10 mL/minute/1.73 m2 reduce dose or frequency; rashes more common.

Source pages 603, 604

Dose and formulations

Extracted information for Ampicillin only.

Directions For Administration

▶With oral use Administer at least 30 minutes before food. ▶With intravenous use in adults For intravenous infusion Infection (Penbritin ®), give intermittently in Glucose 5% or Sodium chloride 0.9%. Reconstituted solutions diluted and given without delay; suggested volume 100 mL given over 30–60 minutes via drip tubing in Glucose 5% or Sodium chloride 0.9%. Continuous infusion not usually recommended.

Source page 604

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Oral suspension CAUTIONARY AND ADVISORY LABELS 9, 23 ▶Ampicillin (Non-proprietary) Ampicillin 25 mg per 1 ml Ampicillin 125mg/5ml oral suspension | 100 ml P £29.86 DT = £29.86 Ampicillin 50 mg per 1 ml Ampicillin 250mg/5ml oral suspension | 100 ml P £38.86 DT = £38.86 Capsule CAUTIONARY AND ADVISORY LABELS 9, 23 ▶Ampicillin (Non-proprietary) Ampicillin 250 mg Ampicillin 250mg capsules | 28 capsule P £20.50 DT = £20.50 Ampicillin 500 mg Ampicillin 500mg capsules | 28 capsule P £40.30 DT = £40.30 Powder for solution for injection ▶Ampicillin (Non-proprietary) Ampicillin (as Ampicillin sodium) 500 mg Ampicillin 500mg powder for solution for injection vials | 10 vial P £78.30 DT = £78.30 eiiii F 575

Source page 604

Clinical care

Extracted information for Ampicillin only.

Patient And Carer Advice

Medicines for Children leaflet: Ampicillin for bacterial infection www.medicinesforchildren.org.uk/ampicillin-bacterial-infection

Source page 604

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

0.5–1 g every 6 hours

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 603

Adults

First line only; read the complete Indications and dose section above.

500 mg every 4–6 hours

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 603

Adults

First line only; read the complete Indications and dose section above.

500 mg every 4–6 hours

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 603

Adults

First line only; read the complete Indications and dose section above.

2 g every 4 hours

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 603

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.

Individual generic drug information

ampicillin

Reference monograph

Part of registered formulation

AMPICILLIN SODIUM

Reference record: Ampicillin
Source: BNF 80 (2020–2021)
Printed source pages: 603, 604
Age groups indexed: 2

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Ampicillin only.

Indications And Dose

Source page 603

Cautions

Source page 603

Safety

Extracted information for Ampicillin only.

Interactions

→Appendix 1: penicillins

Source page 603

Side Effects

Colitis haemorrhagic

Source page 603

Pregnancy

Not known to be harmful.

Source page 603

Breast Feeding

Trace amounts in milk, but appropriate to use.

Source page 603

Renal Impairment

Source pages 603, 604

Dose and formulations

Extracted information for Ampicillin only.

Directions For Administration

Source page 604

Medicinal Forms

Source page 604

Clinical care

Extracted information for Ampicillin only.

Patient And Carer Advice

Medicines for Children leaflet: Ampicillin for bacterial infection www.medicinesforchildren.org.uk/ampicillin-bacterial-infection

Source page 604

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

0.5–1 g every 6 hours

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 603

Adults

First line only; read the complete Indications and dose section above.

500 mg every 4–6 hours

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 603

Adults

First line only; read the complete Indications and dose section above.

500 mg every 4–6 hours

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 603

Adults

First line only; read the complete Indications and dose section above.

2 g every 4 hours

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 603

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.