Therapeutic Action
Penicillin antibacterial
Source page 353
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Individual generic drug information
Extracted information for AMPICILLIN only.
Penicillin antibacterial
Source page 353
Severe bacterial infections: septicaemia, meningitis, pneumonia, pyelonephritis, postpartum upper genital tract infection, severe cutaneous anthrax, etc., alone or in combination with other antibacterials, depending on indication
Source page 353
Extracted information for AMPICILLIN only.
Do not administer to patients with infectious mononucleosis (risk of skin eruption) or to penicillin allergic patients. Administer with caution to patients allergic to cephalosporins (cross-sensitivity may occur) or patients with severe renal impairment (reduce dosage). May cause: skin eruption, gastrointestinal disturbances, allergic reactions sometimes severe. Do not combine with methotrexate (increased methotrexate toxicity). Pregnancy: no contra-indication Breast-feeding: no contra-indication
Source page 354
Extracted information for AMPICILLIN only.
Powder for injection, in 500 mg and 1 g vials, to be dissolved in 5 ml of water for injection Prefer administration by slow IV injection (3 to 5 minutes) or IV infusion (30 minutes) in 0.9% sodium chloride or 5% glucose for high doses; use IM route only if correct IV administration is not possible. In neonates, administer only by slow IV injection or IV infusion.
Source page 353
Severe bacterial infections, in combination with other antibacterials The dose varies according to indication: Neonate: 0 to 7 days (< 2 kg): 50 to 100 mg/kg every 12 hours 0 to 7 days (≥ 2 kg): 50 to 100 mg/kg every 8 hours 8 days to < 1 month: 50 to 100 mg/kg every 8 hours Child 1 month and over: 50 to 100 mg/kg every 8 hours Adult: 1 to 2 g every 6 to 8 hours (2 g every 4 hours in meningitis) Severe cutaneous anthrax, in combination with clindamycin Child 1 month and over: 50 mg/kg (max. 3 g) every 6 hours or 65 mg/kg (max. 4 g) every 8 hours Adult: 3 g every 6 hours or 4 g every 8 hours For administration by IV infusion, dilute each dose of ampicillin in 5 ml/kg of 0.9% sodium chloride or 5% glucose in children less than 20 kg and in a bag of 100 ml of 0.9% sodium chloride or 5% glucose in children 20 kg and over and in adults.
Source page 353
According to indication and clinical response. Change to oral treatment as soon as possible with amoxicillin or a combination of antibacterials, depending on indication.
Source pages 353, 354
Extracted information for AMPICILLIN only.
Do not mix with another drug in the same syringe or infusion. Injectable amoxicillin is used for the same indications.
Source page 354
– Below 25 °C Once reconstituted, the solution must be used immediately.
Source page 354
Filter the extracted dose blocks for this individual drug.
50 to 100 mg/kg every 8 hours
Candidate age grouping · source page 353
50 mg/kg (max. 3 g) every 6 hours or 65 mg/kg (max. 4 g) every 8 hours
Candidate age grouping · source page 353