Therapeutic Action
Macrolide antibacterial
Source page 364
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Individual generic drug information
Extracted information for AZITHROMYCIN only.
Macrolide antibacterial
Source page 364
Macrolide-sensitive severe infections, when oral administration is not possible (e.g. sepsis, diphtheria)
Source page 364
Extracted information for AZITHROMYCIN only.
Do not administer to patients with allergy to azithromycin or another macrolide, nor to patients with severe hepatic impairment. Administer with caution to children under 6 weeks of age (risk of hypertrophic pyloric stenosis) and patients with risk factors for QT prolongation (e.g. electrolyte disturbances, pre-existing cardiac and renal disorders, older patients). May cause: gastrointestinal disturbances, reversible hearing disorders, electrolyte disturbances, QT prolongation; rarely: hypersensitivity reactions (including severe cutaneous reactions such as Stevens- Johnson, Lyell and DRESS syndromes) and life-threatening hepatotoxicity. In these cases, stop treatment. Signs and symptoms of hypersensitivity reaction (e.g. fever, rash, mouth ulcers, bleeding) and hepatic disorders (e.g. anorexia, nausea, general malaise, dark urine, pale stools, hepatomegaly, jaundice) require immediate medical attention. Avoid combination with drugs that prolong the QT interval (amiodarone, chloroquine, co- artemether, fluconazole, haloperidol, mefloquine, moxifloxacin, ondansetron, pentamidine, quinine, etc.). Administer with caution and monitor use in patients taking digoxin (increased digoxin toxicity). Pregnancy and breast-feeding: no contra-indication
Source pages 364, 365
Extracted information for AZITHROMYCIN only.
Powder for injection, in 500 mg vial, to be dissolved in 4.8 ml of water for injection, for IV infusion in 0.9% sodium chloride or 5% glucose DO NOT ADMINISTER BY IV or IM INJECTION.
Source page 364
Sepsis Child: 10 to 20 mg/kg (max. 500 mg) once daily Adult: 500 mg to 1 g once daily Diphtheria Child: 10 to 12 mg/kg (max. 500 mg) once daily Adult: 500 mg once daily Dilute each dose in 0.9% sodium chloride or 5% glucose to obtain a final concentration of 2 mg/ml and administer over 60 minutes. Examples: for a child weighing 15 kg, 150 mg (10 mg x 15 kg) in 75 ml of 0.9% sodium chloride or 5% glucose for an adult, 500 mg in 250 ml (or 1 g in 500 ml) of 0.9% sodium chloride or 5% glucose
Source page 364
Change to oral treatment as soon as possible.
Source page 364
Extracted information for AZITHROMYCIN only.
Do not mix with other drugs in the same infusion.
Source page 365
– Below 25 °C Once reconstituted, the solution must be used immediately; discard any unused open vial.
Source page 365
Filter the extracted dose blocks for this individual drug.
10 to 20 mg/kg (max. 500 mg) once daily
Candidate age grouping · source page 364
10 to 12 mg/kg (max. 500 mg) once daily
Candidate age grouping · source page 364