Individual generic drug information
Extracted information for Brolucizumab only.
Brolucizumab is a monoclonal antibody that inhibits vascular endothelial growth factor A (VEGF-A), thereby suppressing endothelial cell proliferation and inhibiting the growth of new vessels and decreasing vascular permeability.
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Neovascular (wet) age-related macular degeneration (specialist use only) ▶BY INTRAVITREAL INJECTION ▶Adult: Initially 6 mg once a month for the first three doses, to be administered into the affected eye, for continued treatment and subsequent dose intervals— consult product literature, discontinue treatment if no improvement in visual and anatomic outcomes Eye
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Active intra-ocular inflammation. active or suspected ocular or periocular infection
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History of myocardial infarction within the past 3 months. history of stroke within the past 3 months. history of transient ischaemic attack within the past 3 months. patients at risk of retinal pigment epithelial tear . poorly controlled glaucoma (do not use while intra-ocular pressure is 30 mmHg or higher). retinal detachment or macular hole (discontinue treatment if rhegmatogenous retinal detachment or stage 3 or 4 macular holes develop) CAUTIONS, FURTHER INFORMATION Brolucizumab is given by intravitreal injection by specialists experienced in the management of this condition. There is a potential risk of arterial thromboembolic events and non-ocular haemorrhage following the intravitreal injection of vascular endothelial growth factor inhibitors. Endophthalmitis can occur after intravitreal injections— patients should be advised to report any signs of infection immediately.
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Brolucizumab is a biological medicine. Biological medicines must be prescribed and dispensed by brand name, see Biological medicines and Biosimilar medicines, under Guidance on prescribing p. 1; manufacturer advises to record the brand name and batch number after each administration. l HANDLING AND STORAGE Manufacturer advises store in a refrigerator (2-8°C)—may be stored unopened at room temperature (below 25°C) for up to 24 hours before use; protect from light.
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Extracted information for Brolucizumab only.
▶Common or very common Cataract. eye discomfort. eye disorders. eye inflammation. haemorrhage. hypersensitivity. retinal pigment epithelial tear. skin reactions. vision disorders ▶Uncommon Embolism and thrombosis ▶Frequency not known Myocardial infarction. stroke
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Manufacturer advises females of childbearing potential to use effective contraception during treatment and for 1 month after treatment.
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Manufacturer advises avoid unless potential benefit outweighs risk—limited information available.
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Manufacturer advises avoid during and for 1 month after treatment—no information available.
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▶Manufacturer advises monitor intra-ocular pressure, perfusion of the optic nerve head, and for signs of ocular infection following injection. ▶Manufacturer advises monitor visual acuity.
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Extracted information for Brolucizumab only.
For further information on administration, consult product literature.
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There can be variation in the licensing of different medicines containing the same drug. Solution for injection EXCIPIENTS: May contain Polysorbates, sucrose A ▶Beovu (Novartis Pharmaceuticals UK Ltd) Brolucizumab 120 mg per 1 ml Beovu 19.8mg/0.165ml solution for injection pre-filled syringes | 1 pre-filled disposable injection P £816.00 (Hospital only)
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Filter the extracted dose blocks for this individual drug.
First line only; read the complete Indications and dose section above.
Initially 6 mg once a month for the first three
This is a first-line fragment. Read the full Indications and Dose section above.
Candidate age grouping · source page 1276
