Individual generic drug information

cefaclor

Reference monograph

Part of registered formulation

CEFACLOR

Reference record: Cefaclor
Source: BNF 80 (2020–2021)
Printed source pages: 574, 575
Age groups indexed: 2

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Cefaclor only.

Indications And Dose

Susceptible infections due to sensitive Gram-positive and Gram-negative bacteria ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Child 1–11 months: 20 mg/kg daily in 3 divided doses, alternatively 62.5 mg 3 times a day ▶Child 1–4 years: 20 mg/kg daily in 3 divided doses, alternatively 125 mg 3 times a day ▶Child 5–11 years: 20 mg/kg daily in 3 divided doses, usual max. 1 g daily, alternatively 250 mg 3 times a day ▶Child 12–17 years: 250 mg 3 times a day; maximum 4 g per day ▶Adult: 250 mg 3 times a day; maximum 4 g per day ▶BY MOUTH USING MODIFIED-RELEASE MEDICINES ▶Child 12–17 years: 375 mg every 12 hours, dose to be taken with food ▶Adult: 375 mg every 12 hours, dose to be taken with food Severe susceptible infections due to sensitive Gram- positive and Gram-negative bacteria ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Child 1–11 months: 40 mg/kg daily in 3 divided doses, usual max. 1 g daily, alternatively 125 mg 3 times a day ▶Child 1–4 years: 40 mg/kg daily in 3 divided doses, usual max. 1 g daily, alternatively 250 mg 3 times a day ▶Child 5–11 years: 40 mg/kg daily in 3 divided doses, usual max. 1 g daily ▶Child 12–17 years: 500 mg 3 times a day; maximum 4 g per day ▶Adult: 500 mg 3 times a day; maximum 4 g per day Pneumonia ▶BY MOUTH USING MODIFIED-RELEASE TABLETS ▶Child 12–17 years: 750 mg every 12 hours, dose to be taken with food ▶Adult: 750 mg every 12 hours, dose to be taken with food Lower urinary-tract infections ▶BY MOUTH USING MODIFIED-RELEASE MEDICINES ▶Child 12–17 years: 375 mg every 12 hours, dose to be taken with food ▶Adult: 375 mg every 12 hours, dose to be taken with food Asymptomatic carriage of Haemophilus influenzae or mild exacerbations in cystic fibrosis ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Child 1–11 months: 125 mg every 8 hours ▶Child 1–6 years: 250 mg 3 times a day ▶Child 7–17 years: 500 mg 3 times a day

Source pages 574, 575

Safety

Extracted information for Cefaclor only.

Interactions

→Appendix 1: cephalosporins

Source page 575

Side Effects

Akathisia. anxiety. aplastic anaemia. arthralgia. arthritis. asthenia. colitis. confusion. drowsiness. dyspnoea. fever. fungal infection. genital pruritus. hallucination. hepatitis (transient). hypersensitivity. insomnia. jaundice cholestatic (transient). lymphadenopathy. lymphocytosis. muscle tone increased. oedema. paraesthesia. proteinuria. syncope. vasodilation SIDE-EFFECTS, FURTHER INFORMATION Cefaclor is associated with protracted skin reactions, especially in children.

Source page 575

Pregnancy

Not known to be harmful.

Source page 575

Breast Feeding

Present in milk in low concentration, but appropriate to use.

Source page 575

Renal Impairment

Manufacturer advises caution. Dose adjustments No dose adjustment required.

Source page 575

Dose and formulations

Extracted information for Cefaclor only.

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Oral suspension CAUTIONARY AND ADVISORY LABELS 9 ▶Distaclor (Flynn Pharma Ltd) Cefaclor (as Cefaclor monohydrate) 25 mg per 1 ml Distaclor 125mg/5ml oral suspension | 100 ml P £4.13 DT = £4.13 Cefaclor (as Cefaclor monohydrate) 50 mg per 1 ml Distaclor 250mg/5ml oral suspension | 100 ml P £8.26 DT = £8.26 Modified-release tablet CAUTIONARY AND ADVISORY LABELS 9, 21, 25 ▶Distaclor MR (Flynn Pharma Ltd) Cefaclor (as Cefaclor monohydrate) 375 mg Distaclor MR 375mg tablets | 14 tablet P £9.10 DT = £9.10 Capsule CAUTIONARY AND ADVISORY LABELS 9 ▶Distaclor (Flynn Pharma Ltd) Cefaclor (as Cefaclor monohydrate) 500 mg Distaclor 500mg capsules | 21 capsule P £7.50 DT = £7.50 eiiii F 550

Source page 575

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Children

First line only; read the complete Indications and dose section above.

20 mg/kg daily in 3 divided doses,

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 574

Children

First line only; read the complete Indications and dose section above.

20 mg/kg daily in 3 divided doses,

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 574

Children

First line only; read the complete Indications and dose section above.

20 mg/kg daily in 3 divided doses, usual

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 574

Children

First line only; read the complete Indications and dose section above.

250 mg 3 times a day; maximum 4 g

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 574

Children

First line only; read the complete Indications and dose section above.

375 mg every 12 hours, dose to be

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 574

Children

First line only; read the complete Indications and dose section above.

40 mg/kg daily in 3 divided doses,

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 574

Children

First line only; read the complete Indications and dose section above.

40 mg/kg daily in 3 divided doses, usual

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 574

Children

First line only; read the complete Indications and dose section above.

40 mg/kg daily in 3 divided doses, usual

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 574

Children

First line only; read the complete Indications and dose section above.

500 mg 3 times a day; maximum 4 g

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 574

Children

First line only; read the complete Indications and dose section above.

750 mg every 12 hours, dose to be

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 575

Children

First line only; read the complete Indications and dose section above.

375 mg every 12 hours, dose to be

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 575

Children

First line only; read the complete Indications and dose section above.

125 mg every 8 hours

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 575

Children

First line only; read the complete Indications and dose section above.

250 mg 3 times a day

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 575

Children

First line only; read the complete Indications and dose section above.

500 mg 3 times a day

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 575

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.

Individual generic drug information

cefaclor

Reference monograph

Part of registered formulation

CEFACLOR

Reference record: Cefaclor
Source: BNF 80 (2020–2021)
Printed source pages: 574, 575
Age groups indexed: 2

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Cefaclor only.

Indications And Dose

Source pages 574, 575

Safety

Extracted information for Cefaclor only.

Interactions

→Appendix 1: cephalosporins

Source page 575

Side Effects

Source page 575

Pregnancy

Not known to be harmful.

Source page 575

Breast Feeding

Present in milk in low concentration, but appropriate to use.

Source page 575

Renal Impairment

Manufacturer advises caution. Dose adjustments No dose adjustment required.

Source page 575

Dose and formulations

Extracted information for Cefaclor only.

Medicinal Forms

Source page 575

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Children

First line only; read the complete Indications and dose section above.

20 mg/kg daily in 3 divided doses,

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 574

Children

First line only; read the complete Indications and dose section above.

20 mg/kg daily in 3 divided doses,

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 574

Children

First line only; read the complete Indications and dose section above.

20 mg/kg daily in 3 divided doses, usual

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 574

Children

First line only; read the complete Indications and dose section above.

250 mg 3 times a day; maximum 4 g

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 574

Children

First line only; read the complete Indications and dose section above.

375 mg every 12 hours, dose to be

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 574

Children

First line only; read the complete Indications and dose section above.

40 mg/kg daily in 3 divided doses,

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 574

Children

First line only; read the complete Indications and dose section above.

40 mg/kg daily in 3 divided doses, usual

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 574

Children

First line only; read the complete Indications and dose section above.

40 mg/kg daily in 3 divided doses, usual

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 574

Children

First line only; read the complete Indications and dose section above.

500 mg 3 times a day; maximum 4 g

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 574

Children

First line only; read the complete Indications and dose section above.

750 mg every 12 hours, dose to be

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 575

Children

First line only; read the complete Indications and dose section above.

375 mg every 12 hours, dose to be

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 575

Children

First line only; read the complete Indications and dose section above.

125 mg every 8 hours

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 575

Children

First line only; read the complete Indications and dose section above.

250 mg 3 times a day

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 575

Children

First line only; read the complete Indications and dose section above.

500 mg 3 times a day

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 575

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.