Therapeutic Action
Lincosamide antibacterial
Source page 381
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Individual generic drug information
Extracted information for CLINDAMYCIN only.
Lincosamide antibacterial
Source page 381
Second-line treatment of severe infections due to anaerobic bacteria, staphylococci and/or streptococci (e.g. cellulitis, erysipelas, pneumonia, septicaemia), alone or in combination with other antibacterials, depending on indication Necrotizing skin and soft tissues infections (necrotizing fasciitis, gas gangrene, etc.), severe cutaneous anthrax, in combination with other antibacterials
Source page 381
Extracted information for CLINDAMYCIN only.
Do not administer to patients with allergy to lincosamides or history of pseudomembranous colitis. Reduce dosage in patients with hepatic impairment. May cause: pseudomembranous colitis, rash, jaundice, severe allergic reactions. In these cases, stop treatment. In the event of pseudomembranous colitis, treat for Clostridium difficile infection (oral metronidazole). Pregnancy: no contra-indication Breast-feeding: use only when there are no therapeutic alternative. Check child's stools (risk of pseudomembranous colitis).
Source page 382
Extracted information for CLINDAMYCIN only.
300 mg in 2 ml ampoule (150 mg/ml), for IV infusion in 0.9% sodium chloride or 5% glucose, to be administered over 30 minutes. NEVER USE BY DIRECT UNDILUTED IV.
Source page 381
Severe infections due to anaerobic bacteria, staphylococci and/or streptococci Neonate 0 to 7 days (< 2 kg): 5 mg/kg every 12 hours Neonate 0 to 7 days (≥ 2 kg): 5 mg/kg every 8 hours Neonate 8 days to < 1 month (< 2 kg): 5 mg/kg every 8 hours Neonate 8 days to < 1 month (≥ 2 kg): 10 mg/kg every 8 hours Child 1 month and over: 10 mg/kg (max. 600 mg) every 8 hours Adult: 600 to 900 mg every 8 hours Necrotizing infections, severe cutaneous anthrax Neonate: as above Child 1 month and over: 10 to 13 mg/kg (max. 900 mg) every 8 hours Adult: 900 mg every 8 hours Dilute each dose of clindamycin in 5 ml/kg of 0.9% sodium chloride or 5% glucose in children less than 20 kg and in a bag of 100 ml of 0.9% sodium chloride or 5% glucose in children 20 kg and over and in adults.
Source page 381
Cellulitis, erysipelas: 7 to 10 days Pneumonia: 10 to 14 days Severe cutaneous anthrax: 14 days Other infections: according to clinical evolution Change to oral route as soon as possible.
Source page 382
Extracted information for CLINDAMYCIN only.
Do not mix with other drugs in the same infusion. Some formulations contain benzyl alcohol and should not be used in neonates.
Source page 382
– Below 25 °C
Source page 382
Filter the extracted dose blocks for this individual drug.
600 to 900 mg every 8 hours
Candidate age grouping · source page 381
900 mg every 8 hours
Candidate age grouping · source page 381