Individual generic drug information

gentamicin

Reference monograph

Part of registered formulation

CLOTRIMAZOLE + GENTAMICIN SULFATE + BETAMETHASONE DIPROPIONATE

Reference record: Gentamicin
Source: BNF 80 (2020–2021)
Printed source pages: 567
Age groups indexed: 1

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Gentamicin only.

Indications And Dose

Moderate diabetic foot infection | Severe diabetic foot infection | Acute diverticulitis [in combination with amoxicillin and metronidazole] ▶BY INTRAVENOUS INFUSION ▶Adult: Initially 5–7 mg/kg once daily, subsequent doses adjusted according to serum-gentamicin concentration Gram-positive bacterial endocarditis or HACEK endocarditis (in combination with other antibacterials) ▶BY INTRAMUSCULAR INJECTION, OR BY SLOW INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult: 1 mg/kg every 12 hours, intravenous injection to be administered over at least 3 minutes, to be given in a multiple daily dose regimen Septicaemia | Meningitis and other CNS infections | Biliary- tract infection | Endocarditis | Pneumonia in hospital patients | Adjunct in listerial meningitis | Prostatitis ▶BY INTRAVENOUS INFUSION, OR BY SLOW INTRAVENOUS INJECTION, OR BY INTRAMUSCULAR INJECTION ▶Adult: 3–5 mg/kg daily in 3 divided doses, to be given in a multiple daily dose regimen, divided doses to be given every 8 hours, intravenous injection to be administered over at least 3 minutes ▶BY INTRAVENOUS INFUSION ▶Adult: Initially 5–7 mg/kg, subsequent doses adjusted according to serum-gentamicin concentration, to be given in a once daily dose regimen CNS infections (administered on expert advice) ▶BY INTRATHECAL INJECTION ▶Adult: 1 mg daily, increased if necessary to 5 mg daily, seek specialist advice Surgical prophylaxis ▶BY SLOW INTRAVENOUS INJECTION ▶Adult: 1.5 mg/kg, intravenous injection to be administered over at least 3 minutes, administer dose up to 30 minutes before the procedure, dose may be repeated every 8 hours for high-risk procedures; up to 3 further doses may be given Surgical prophylaxis in joint replacement surgery ▶BY INTRAVENOUS INFUSION ▶Adult: 5 mg/kg for 1 dose, administer dose up to 30 minutes before the procedure Acute pyelonephritis (once daily dose regimen) | Urinary tract infection (catheter-associated, once daily dose regimen) ▶BY INTRAVENOUS INFUSION ▶Adult: Initially 5–7 mg/kg once daily, subsequent doses adjusted according to serum-gentamicin concentration DOSES AT EXTREMES OF BODY-WEIGHT ▶With intramuscular use or intravenous use To avoid excessive dosage in obese patients, use ideal weight for height to calculate parenteral dose and monitor serum-gentamicin concentration closely. l UNLICENSED USE Gentamicin doses in BNF publications may differ from those in product literature.

Source page 567

Prescribing And Dispensing Information

▶With intravenous use Local guidelines may vary in the dosing advice provided for once daily administration. ▶With intrathecal use Only preservative-free intrathecal preparation should be used.

Source page 567

Safety

Extracted information for Gentamicin only.

Important Safety Information

MHRA/CHM ADVICE: POTENTIAL FOR HISTAMINE-RELATED ADVERSE DRUG REACTIONS WITH SOME BATCHES (NOVEMBER 2017) Following reports that some batches of gentamicin sulphate active pharmaceutical ingredient (API) used to manufacture gentamicin may contain higher than expected levels of histamine, which is a residual from the manufacturing process, the MHRA advise to monitor patients for signs of histamine-related adverse reactions; particular caution is required in patients taking concomitant drugs known to cause histamine release, in children, and in patients with severe renal impairment.

Source page 567

Interactions

→Appendix 1: aminoglycosides

Source page 567

Side Effects

Antibiotic associated colitis. blood disorder . depression. encephalopathy. hallucination. hepatic Infection reaction. neurotoxicity. peripheral neuropathy. seizure. stomatitis. vestibular damage

Source page 567

Monitoring Requirements

▶With intramuscular use or intravenous use For multiple daily dose regimen, one-hour (‘peak’) serum concentration should be 5–10 mg/litre; pre-dose (‘trough’) concentration should be less than 2 mg/litre. For multiple daily dose regimen in endocarditis, one-hour (‘peak’) serum concentration should be 3–5 mg/litre; pre-dose (‘trough’) concentration should be less than 1 mg/litre. Serum- gentamicin concentration should be measured after 3 or 4 doses, then at least every 3 days and after a dose change (more frequently in renal impairment). ▶With intravenous use For once-daily dose regimen, consult local guidelines on monitoring serum-gentamicin concentration.

Source page 567

Dose and formulations

Extracted information for Gentamicin only.

Directions For Administration

▶With intrathecal use For intrathecal injection, use preservative-free intrathecal preparations only. ▶With intravenous use For intravenous infusion (Cidomycin ®); Gentamicin paediatric injection, Beacon; Gentamicin injection Hospira), give intermittently or via drip tubing in Glucose 5% or Sodium Chloride 0.9%. Suggested volume for intermittent infusion 50–100 ml given over 20–30 minutes (given over 60 minutes for once daily dose regimen).

Source page 567

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Solution for injection ▶Gentamicin (Non-proprietary) Gentamicin (as Gentamicin sulfate) 5 mg per 1 ml Gentamicin Intrathecal 5mg/1ml solution for injection ampoules | 5 ampoule P £36.28 DT = £36.28 (Hospital only) Gentamicin (as Gentamicin sulfate) 10 mg per 1 ml Gentamicin 20mg/2ml solution for injection ampoules | 5 ampoule P £11.25 DT = £11.25 Gentamicin Paediatric 20mg/2ml solution for injection vials | 5 vial P £11.25 DT = £11.25 Gentamicin (as Gentamicin sulfate) 40 mg per 1 ml Gentamicin 80mg/2ml solution for injection vials | 5 vial P £20.00 DT = £6.88 (Hospital only) Gentamicin 80mg/2ml solution for injection ampoules | 5 ampoule P £6.88 DT = £6.88 | 10 ampoule P £12.00 ▶Cidomycin (Sanofi) Gentamicin (as Gentamicin sulfate) 40 mg per 1 ml Cidomycin 80mg/2ml solution for injection vials | 5 vial P £6.88 DT = £6.88 Cidomycin 80mg/2ml solution for injection ampoules | 5 ampoule P £6.88 DT = £6.88 Infusion ▶Gentamicin (Non-proprietary) Gentamicin (as Gentamicin sulfate) 1 mg per 1 ml Gentamicin 80mg/80ml infusion bags | 20 bag P £40.17–£44.19 Gentamicin (as Gentamicin sulfate) 3 mg per 1 ml Gentamicin 240mg/80ml infusion bags | 20 bag P £122.58–£134.83 Gentamicin 360mg/120ml infusion bags | 20 bag P £174.07– £191.48

Source page 567

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

Initially 5–7 mg/kg once daily, subsequent doses

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 567

Adults

First line only; read the complete Indications and dose section above.

1 mg/kg every 12 hours, intravenous injection to

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 567

Adults

First line only; read the complete Indications and dose section above.

3–5 mg/kg daily in 3 divided doses, to be given

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 567

Adults

First line only; read the complete Indications and dose section above.

Initially 5–7 mg/kg, subsequent doses adjusted

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 567

Adults

First line only; read the complete Indications and dose section above.

1 mg daily, increased if necessary to 5 mg daily,

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 567

Adults

First line only; read the complete Indications and dose section above.

1.5 mg/kg, intravenous injection to be

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 567

Adults

First line only; read the complete Indications and dose section above.

5 mg/kg for 1 dose, administer dose up to

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 567

Adults

First line only; read the complete Indications and dose section above.

Initially 5–7 mg/kg once daily, subsequent doses

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 567

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.

Individual generic drug information

gentamicin

Reference monograph

Part of registered formulation

CLOTRIMAZOLE + GENTAMICIN SULFATE + BETAMETHASONE DIPROPIONATE

Reference record: Gentamicin
Source: BNF 80 (2020–2021)
Printed source pages: 567
Age groups indexed: 1

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Gentamicin only.

Indications And Dose

Source page 567

Prescribing And Dispensing Information

▶With intravenous use Local guidelines may vary in the dosing advice provided for once daily administration. ▶With intrathecal use Only preservative-free intrathecal preparation should be used.

Source page 567

Safety

Extracted information for Gentamicin only.

Important Safety Information

Source page 567

Interactions

→Appendix 1: aminoglycosides

Source page 567

Side Effects

Antibiotic associated colitis. blood disorder . depression. encephalopathy. hallucination. hepatic Infection reaction. neurotoxicity. peripheral neuropathy. seizure. stomatitis. vestibular damage

Source page 567

Monitoring Requirements

Source page 567

Dose and formulations

Extracted information for Gentamicin only.

Directions For Administration

Source page 567

Medicinal Forms

Source page 567

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

Initially 5–7 mg/kg once daily, subsequent doses

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 567

Adults

First line only; read the complete Indications and dose section above.

1 mg/kg every 12 hours, intravenous injection to

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 567

Adults

First line only; read the complete Indications and dose section above.

3–5 mg/kg daily in 3 divided doses, to be given

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 567

Adults

First line only; read the complete Indications and dose section above.

Initially 5–7 mg/kg, subsequent doses adjusted

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 567

Adults

First line only; read the complete Indications and dose section above.

1 mg daily, increased if necessary to 5 mg daily,

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 567

Adults

First line only; read the complete Indications and dose section above.

1.5 mg/kg, intravenous injection to be

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 567

Adults

First line only; read the complete Indications and dose section above.

5 mg/kg for 1 dose, administer dose up to

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 567

Adults

First line only; read the complete Indications and dose section above.

Initially 5–7 mg/kg once daily, subsequent doses

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 567

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.