Therapeutic Action
Antiretroviral, HIV protease inhibitor
Source page 108
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Individual generic drug information
Extracted information for DARUNAVIR only.
Antiretroviral, HIV protease inhibitor
Source page 108
HIV infection, in combination with ritonavir (booster) and other antiretrovirals
Source page 108
Extracted information for DARUNAVIR only.
Do not administer to children under 3 years; and to patients with severe hepatic impairment or allergy to sulfonamides (risk of cross-sensitivity). Do not combine with rifampicin (decreased plasma concentrations of darunavir). Replace rifampicin with rifabutin. Administer with caution and monitor use in patients with haemophilia (increased bleeding) or mild to moderate hepatic impairment. May cause: gastrointestinal disturbances, headache, insomnia, fatigue, dizziness, peripheral neuropathy, renal disorders, myocardial infarction, hypertension, tachycardia, hyperglycaemia, hyperlipidaemia, lipodystrophy; skin rash sometimes severe, hepatic disorders; in this event, stop treatment immediately. Darunavir in combination with ritonavir reduces the efficacy of implants and oral contraceptives: use injectable medroxyprogesterone or an intrauterine device. Pregnancy: no contra-indication; use 2 times daily dosing due to decreased plasma concentrations of darunavir during pregnancy.
Source pages 108, 109
Extracted information for DARUNAVIR only.
75 mg, 150 mg, 400 mg and 600 mg tablets 400 mg darunavir/50 mg ritonavir tablet
Source page 108
Patients with no previous use of protease inhibitors Single formulations Child 14 to < 35 kg: 600 mg once daily (+ 100 mg ritonavir once daily) Child ≥ 35 kg and adult: 800 mg once daily (+ 100 mg ritonavir once daily) Fixed-dose combination Child ≥ 40 kg and ≥ 12 years and adult: two 400/50 mg tablets once daily Patients with previous use of protease inhibitors Single formulations Child 14 to < 25 kg: 375 mg 2 times daily (+ 50 mg ritonavir 2 times daily) Child 25 to < 35 kg: 400 mg 2 times daily (+ 100 mg ritonavir 2 times daily) Child ≥ 35 kg and adult: 600 mg 2 times daily (+ 100 mg ritonavir 2 times daily)
Source page 108
Depending on the efficacy and tolerance of darunavir and ritonavir.
Source page 108
Extracted information for DARUNAVIR only.
Take with meals together with ritonavir.
Source page 109
– Below 25 °C
Source page 109
Filter the extracted dose blocks for this individual drug.
800 mg once daily (+ 100 mg ritonavir once daily)
Candidate age grouping · source page 108
two 400/50 mg tablets once daily
Candidate age grouping · source page 108
600 mg 2 times daily (+ 100 mg ritonavir 2 times daily)
Candidate age grouping · source page 108