Individual generic drug information

dinoprostone

Reference monograph

Part of registered formulation

DINOPROSTONE

Reference record: Dinoprostone
Source: BNF 80 (2020–2021)
Printed source pages: 891
Age groups indexed: 1

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Dinoprostone only.

Indications And Dose

PROPESS ® Cervical ripening and induction of labour at term ▶BY VAGINA ▶Adult: 1 pessary, insert pessary (in retrieval device) high into posterior fornix and remove when cervical ripening adequate; if oxytocin necessary, remove 30 minutes before oxytocin infusion; remove if cervical ripening inadequate after 24 hours (dose not to be repeated) PROSTIN E2 ® VAGINAL GEL Induction of labour ▶BY VAGINA ▶Adult: 1 mg, inserted high into the posterior fornix (avoid administration into the cervical canal), followed by 1–2 mg after 6 hours if required; maximum 3 mg per course Induction of labour (unfavourable primigravida) ▶BY VAGINA ▶Adult: 2 mg, inserted high into the posterior fornix (avoid administration into the cervical canal), followed by 1–2 mg if required, after 6 hours; maximum 4 mg per course PROSTIN E2 ® VAGINAL TABLETS Induction of labour ▶BY VAGINA ▶Adult: 3 mg, inserted high into the posterior fornix, followed by 3 mg after 6–8 hours, to be given if labour not established; maximum 6 mg per course DOSE EQUIVALENCE AND CONVERSION ▶Prostin E2 Vaginal tablets and Vaginal Gel are not bioequivalent.

Source page 891

Contra Indications

Active cardiac disease. active pulmonary disease. avoid extra-amniotic route in cervicitis or vaginitis. fetal distress. fetal malpresentation . grand multiparas. history of caesarean section. history of difﬁcult or traumatic delivery. history of major uterine surgery. major cephalopelvic disproportion. multiple pregnancy. placenta praevia or unexplained vaginal bleeding during pregnancy. ruptured membranes. untreated pelvic infection

Source page 891

Cautions

Effect of oxytocin enhanced. history of asthma . history of epilepsy. history of glaucoma and raised intra- ocular pressure. hypertension. risk factors for disseminated intravascular coagulation. uterine rupture. uterine scarring

Source page 891

Prescribing And Dispensing Information

Important: Do not confuse dose of Prostin E2 ®vaginal gel with that of Prostin E2 ®vaginal tablets—not bioequivalent. l LESS SUITABLE FOR PRESCRIBING Intravenous solution rarely used and is considered less suitable for prescribing. Extra-amniotic solution less commonly used and is considered less suitable for prescribing.

Source page 891

Safety

Extracted information for Dinoprostone only.

Side Effects

▶Uncommon Amniotic cavity infection. febrile disorders. headache. hyperbilirubinaemia neonatal. hypotension. pruritus. uterine atony. vaginal burning ▶Rare or very rare Disseminated intravascular coagulation ▶Frequency not known Abdominal pain. diarrhoea. genital oedema. nausea. uterine rupture. vomiting

Source page 891

Hepatic Impairment

Manufacturer advises avoid.

Source page 891

Renal Impairment

Manufacturers advise avoid.

Source page 891

Monitoring Requirements

▶Monitor for disseminated intravascular coagulation after Genito-urinary system parturition. ▶Monitor uterine activity and fetal status (particular care if history of uterine hypertony) ▶Care needed in monitoring uterine activity when used in sequence following oxytocin.

Source page 891

Dose and formulations

Extracted information for Dinoprostone only.

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Pessary ▶Prostin E2 (Pfizer Ltd) Dinoprostone 3 mg Prostin E2 3mg vaginal tablets | 8 pessary P £106.23 (Hospital only) Vaginal gel ▶Prostin E2 (Pfizer Ltd) Dinoprostone 400 microgram per 1 ml Prostin E2 1mg vaginal gel | 2.5 ml P £13.28 (Hospital only) Dinoprostone 800 microgram per 1 ml Prostin E2 2mg vaginal gel | 2.5 ml P £13.28 (Hospital only) Vaginal device ▶Propess (Ferring Pharmaceuticals Ltd) Dinoprostone 10 mg Propess 10mg vaginal delivery system | 5 device P £165.00 5.2 Postpartum haemorrhage Other drugs used for Postpartum haemorrhage Oxytocin, p. 868 ERGOT ALKALOIDS

Source page 891

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

1 pessary, insert pessary (in retrieval device)

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 891

Adults

First line only; read the complete Indications and dose section above.

1 mg, inserted high into the posterior fornix

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 891

Adults

First line only; read the complete Indications and dose section above.

2 mg, inserted high into the posterior fornix

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 891

Adults

First line only; read the complete Indications and dose section above.

3 mg, inserted high into the posterior fornix,

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 891

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.

Individual generic drug information

dinoprostone

Reference monograph

Part of registered formulation

DINOPROSTONE

Reference record: Dinoprostone
Source: BNF 80 (2020–2021)
Printed source pages: 891
Age groups indexed: 1

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Dinoprostone only.

Indications And Dose

Source page 891

Contra Indications

Source page 891

Cautions

Source page 891

Prescribing And Dispensing Information

Source page 891

Safety

Extracted information for Dinoprostone only.

Side Effects

Source page 891

Hepatic Impairment

Manufacturer advises avoid.

Source page 891

Renal Impairment

Manufacturers advise avoid.

Source page 891

Monitoring Requirements

Source page 891

Dose and formulations

Extracted information for Dinoprostone only.

Medicinal Forms

Source page 891

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

1 pessary, insert pessary (in retrieval device)

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 891

Adults

First line only; read the complete Indications and dose section above.

1 mg, inserted high into the posterior fornix

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 891

Adults

First line only; read the complete Indications and dose section above.

2 mg, inserted high into the posterior fornix

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 891

Adults

First line only; read the complete Indications and dose section above.

3 mg, inserted high into the posterior fornix,

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 891

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.