Indications And Dose
Susceptible infections (e.g. chlamydia, rickettsia and mycoplasma) ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Child 12–17 years: Initially 200 mg daily in 1–2 divided doses for 1 day, then maintenance 100 mg daily ▶Adult: Initially 200 mg daily in 1–2 divided doses for 1 day, then maintenance 100 mg daily Severe infections (including refractory urinary-tract infections) ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Child 12–17 years: 200 mg daily ▶Adult: 200 mg daily Acute sinusitis | Acute cough [if systemically very unwell or at higher risk of complications] | Community-acquired pneumonia ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Child 12–17 years: Initially 200 mg daily for 1 dose, then maintenance 100 mg once daily for 5 days in total ▶Adult: Initially 200 mg daily for 1 dose, then maintenance 100 mg once daily for 5 days in total Hospital-acquired pneumonia ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Adult: Initially 200 mg daily for 1 dose, then maintenance 100 mg once daily for 5 days in total then review Acute exacerbation of bronchiectasis ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Child 12–17 years: Initially 200 mg daily for 1 dose, then maintenance 100 mg once daily for 7–14 days in total ▶Adult: Initially 200 mg daily for 1 dose, then maintenance 100 mg once daily for 7–14 days in total Acute exacerbation of chronic obstructive pulmonary disease ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Adult: Initially 200 mg daily for 1 dose, then maintenance 100 mg once daily for 5 days in total, increased if necessary to 200 mg once daily, increased dose used in severe infections Mild diabetic foot infection ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Adult: Initially 200 mg daily for 1 dose, then maintenance 100 mg once daily for 7 days in total then review, increased if necessary to 200 mg once daily Cellulitis | Erysipelas ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Adult: Initially 200 mg daily for 1 dose, then maintenance 100 mg once daily for 5–7 days in total continued → then review Leg ulcer infection ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Adult: Initially 200 mg daily for 1 dose, then maintenance 100 mg once daily for 7 days in total, increased if necessary to 200 mg once daily Acne ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Child 12–17 years: 100 mg once daily Infection ▶Adult: 100 mg once daily Rosacea ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Adult: 100 mg once daily Papulopustular facial rosacea (without ocular involvement) ▶BY MOUTH USING MODIFIED-RELEASE MEDICINES ▶Adult: 40 mg once daily for 16 weeks, dose to be taken in the morning, consider discontinuing treatment if no response after 6 weeks Early syphilis ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Child 12–17 years: 100 mg twice daily for 14 days ▶Adult: 100 mg twice daily for 14 days Late latent syphilis ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Child 12–17 years: 100 mg twice daily for 28 days ▶Adult: 100 mg twice daily for 28 days Neurosyphilis ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Adult: 200 mg twice daily for 28 days Uncomplicated genital chlamydia| Non-gonococcal urethritis ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Child 12–17 years: 100 mg twice daily for 7 days ▶Adult: 100 mg twice daily for 7 days Pelvic inflammatory disease ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Child 12–17 years: 100 mg twice daily for 14 days ▶Adult: 100 mg twice daily for 14 days Lyme disease [erythema migrans and/or non-focal symptoms] | Lyme disease [affecting cranial nerves or peripheral nervous system] | Lyme carditis ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Adult: 200 mg daily in 1–2 divided doses for 21 days Lyme disease [affecting central nervous system] ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Adult: 400 mg daily in 1–2 divided doses for 21 days Lyme arthritis | Acrodermatitis chronica atrophicans ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Adult: 200 mg daily in 1–2 divided doses for 28 days Anthrax (treatment or post-exposure prophylaxis) ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Child 12–17 years: 100 mg twice daily ▶Adult: 100 mg twice daily Prophylaxis of malaria ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Child 12–17 years: 100 mg once daily, to be started 1–2 days before entering endemic area and continued for 4 weeks after leaving, can be used for up to 2 years ▶Adult: 100 mg once daily, to be started 1–2 days before entering endemic area and continued for 4 weeks after leaving, can be used for up to 2 years Adjunct to quinine in treatment of Plasmodium falciparum malaria ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Child 12–17 years: 200 mg daily for 7 days ▶Adult: 200 mg daily for 7 days Periodontitis (as an adjunct to gingival scaling and root planing) ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Child 12–17 years: 20 mg twice daily for 3 months ▶Adult: 20 mg twice daily for 3 months Rocky Mountain spotted fever ▶BY MOUTH USING DISPERSIBLE TABLETS ▶Adult: 100 mg twice daily, continue treatment for at least 3 days after fever subsides, minimum treatment duration is 5–7 days l UNLICENSED USE Doxycycline may be used as detailed below, although these situations are considered outside the scope of its licence: . g Duration of treatment for acute sinusitis; . Lyme disease h; . treatment or post-exposure prophylaxis of anthrax; . malaria prophylaxis during pregnancy. ▶In adults Immediate-release doxycycline may be used for the treatment of rosacea, but it is not licensed for this indication.
Source pages 619, 620