Drug Action
A specific inhibitor of the enzyme 5a- reductase, which metabolises testosterone into the more potent androgen, dihydrotestosterone.
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Individual generic drug information
Extracted information for Dutasteride only.
A specific inhibitor of the enzyme 5a- reductase, which metabolises testosterone into the more potent androgen, dihydrotestosterone.
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Benign prostatic hyperplasia ▶BY MOUTH ▶Adult: 500 micrograms daily, review treatment at 3–6 months and then every 6–12 months (may require several months treatment before benefit is obtained)
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Extracted information for Dutasteride only.
→Appendix 1: dutasteride
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▶Common or very common Breast disorder. sexual dysfunction ▶Uncommon Alopecia. hypertrichosis ▶Frequency not known Angioedema. depressed mood. hypersensitivity. localised oedema. skin reactions. testicular disorders
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Dutasteride is excreted in semen and use of a condom is recommended if sexual partner is pregnant or likely to become pregnant.
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Manufacturer advises caution in mild to moderate impairment; avoid in severe impairment (no information available).
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Manufacturer advises that patients should be regularly evaluated for prostate cancer. l EFFECT ON LABORATORY TESTS May decrease serum concentration of prostate cancer markers such as prostate- specific antigen; reference values may need adjustment. l HANDLING AND STORAGE Women of childbearing potential should avoid handling leaking capsules of dutasteride.
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Extracted information for Dutasteride only.
There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral solution Capsule CAUTIONARY AND ADVISORY LABELS 25 ▶Dutasteride (Non-proprietary) Dutasteride 500 microgram Dutasteride 500microgram capsules | 30 capsule P £19.99 DT = £2.79 ▶Avodart (GlaxoSmithKline UK Ltd) Dutasteride 500 microgram Avodart 500microgram capsules | 30 capsule P £14.60 DT = £2.79 Combinations available: Tamsulosin with dutasteride, p. 829
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Extracted information for Dutasteride only.
Cases of male breast cancer have been reported. Patients or their carers should be told to promptly report to their doctor any changes in breast tissue such as lumps, pain, or nipple discharge.
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Filter the extracted dose blocks for this individual drug.
First line only; read the complete Indications and dose section above.
500 micrograms daily, review treatment at
This is a first-line fragment. Read the full Indications and Dose section above.
Candidate age grouping · source page 852