Indications And Dose
HIV infection in combination with other antiretroviral drugs ▶BY MOUTH USING CAPSULES ▶Adult: 600 mg once daily ▶BY MOUTH USING TABLETS ▶Adult: 600 mg once daily
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Individual generic drug information
Extracted information for Efavirenz only.
HIV infection in combination with other antiretroviral drugs ▶BY MOUTH USING CAPSULES ▶Adult: 600 mg once daily ▶BY MOUTH USING TABLETS ▶Adult: 600 mg once daily
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Acute porphyrias p. 1120. elderly. history of psychiatric disorders. history of seizures
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Extracted information for Efavirenz only.
→Appendix 1: efavirenz
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▶Common or very common Abdominal pain. anxiety. concentration impaired. depression. diarrhoea. dizziness . drowsiness. dyslipidaemia. fatigue. headache. movement disorders. nausea. skin reactions. sleep disorders. vomiting ▶Uncommon Behaviour abnormal. confusion. flushing. gynaecomastia. hallucination. hepatic disorders. memory loss. mood altered. pancreatitis. psychosis. seizure. Stevens-Johnson syndrome. suicidal tendencies. thinking abnormal. tinnitus. tremor. vertigo. vision blurred ▶Rare or very rare Delusions. photosensitivity reaction ▶Frequency not known Immune reconstitution inflammatory syndrome. osteonecrosis SIDE-EFFECTS, FURTHER INFORMATION Rash Rash, usually in the first 2 weeks, is the most common side- effect; discontinue if severe rash with blistering, desquamation, mucosal involvement or fever; if rash mild or moderate, may continue without interruption—usually resolves within 1 month. CNS effects Administration at bedtime especially in first 2–4 weeks reduces CNS effects. Abnormal hepatic function Manufacturer advises interrupt or discontinue treatment if transaminases more than 5 times the upper limit of normal.
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Reports of neural tube defects when used in first trimester.
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Greater risk of hepatic side-effects in chronic hepatitis B or C. Manufacturer advises avoid in severe impairment (limited information available).
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Manufacturer advises caution in severe renal failure—no information available.
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Monitor liver function if receiving other hepatotoxic drugs.
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Extracted information for Efavirenz only.
For patients who cannot swallow capsules, the capsule may be opened and contents added to a small amount of food—consult product literature. No additional food should be consumed for up to 2 hours after administration of efavirenz.
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There can be variation in the licensing of different medicines containing the same drug. Tablet CAUTIONARY AND ADVISORY LABELS 23 ▶Efavirenz (Non-proprietary) Efavirenz 600 mg Efavirenz 600mg tablets | 30 tablet P £31.35–£452.94 | 30 tablet P £31.41 (Hospital only) ▶Sustiva (Bristol-Myers Squibb Pharmaceuticals Ltd) Efavirenz 600 mg Sustiva 600mg tablets | 30 tablet P £200.27 Infection (Hospital only) Capsule CAUTIONARY AND ADVISORY LABELS 23 ▶Sustiva (Bristol-Myers Squibb Pharmaceuticals Ltd) Efavirenz 50 mg Sustiva 50mg capsules | 30 capsule P £16.73 (Hospital only) Efavirenz 100 mg Sustiva 100mg capsules | 30 capsule P £33.41 (Hospital only) Efavirenz 200 mg Sustiva 200mg capsules | 90 capsule P £200.27 (Hospital only) Combinations available: Efavirenz with emtricitabine and tenofovir disoproxil, p. 685
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Extracted information for Efavirenz only.
Psychiatric disorders Patients or their carers should be advised to seek immediate medical attention if symptoms such as severe depression, psychosis or suicidal ideation occur.
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Filter the extracted dose blocks for this individual drug.
First line only; read the complete Indications and dose section above.
600 mg once daily
This is a first-line fragment. Read the full Indications and Dose section above.
Candidate age grouping · source page 703
First line only; read the complete Indications and dose section above.
600 mg once daily
This is a first-line fragment. Read the full Indications and Dose section above.
Candidate age grouping · source page 703