Individual generic drug information
Extracted information for Eplerenone only.
Adjunct in stable patients with left ventricular ejection fraction 40% with evidence of heart failure, following myocardial infarction (start therapy within 3–14 days of event) | Adjunct in chronic mild heart failure with left ventricular ejection fraction 30% ▶BY MOUTH ▶Adult: Initially 25 mg daily, then increased to 50 mg daily, increased within 4 weeks of initial treatment
Source page 227
DUE TO INTERACTIONS ▶Manufacturer advises max. dose 25 mg daily with concurrent use of amiodarone or moderate inhibitors of CYP3A4.
Source page 227
Hyperkalaemia
Source page 227
Elderly CAUTIONS, FURTHER INFORMATION ▶Elderly For aldosterone antagonists, prescription potentially inappropriate (STOPP criteria) with concurrent potassium-conserving drugs without monitoring of serum potassium (risk of dangerous hyperkalaemia). See also Prescribing in the elderly p. 33.
Source page 227
Extracted information for Eplerenone only.
→Appendix 1: aldosterone antagonists
Source page 227
▶Common or very common Arrhythmias. asthenia. constipation. cough. diarrhoea. dizziness. dyslipidaemia. electrolyte imbalance. headache. insomnia. muscle spasms. nausea. pain. renal impairment. skin reactions. syncope. vomiting ▶Uncommon Angioedema. arterial thrombosis. cholecystitis. eosinophilia. flatulence. gynaecomastia. Cardiovascular system hyperhidrosis. hypothyroidism. increased risk of infection . malaise. numbness. postural hypotension
Source pages 227, 228
Manufacturer advises caution—no information available.
Source page 228
Manufacturer advises use only if potential benefit outweighs risk.
Source page 228
Manufacturer advises avoid in severe impairment (no information available).
Source page 228
Avoid if eGFR less than 30 mL/minute/1.73 m2. Dose adjustments Initially 25 mg on alternate days if eGFR 30–60 mL/minute/1.73 m2, adjust dose according to serum-potassium concentration—consult product literature. Monitoring Increased risk of hyperkalaemia in renal impairment—close monitoring required.
Source page 228
Monitor plasma-potassium concentration before treatment, during initiation, and when dose changed.
Source page 228
Extracted information for Eplerenone only.
There can be variation in the licensing of different medicines containing the same drug. Tablet ▶Eplerenone (Non-proprietary) Eplerenone 25 mg Eplerenone 25mg tablets | 28 tablet P £42.72 DT = £4.43 | 30 tablet P £24.95 Eplerenone 50 mg Eplerenone 50mg tablets | 28 tablet P £42.72 DT = £5.87 | 30 tablet P £24.95 ▶Inspra (Upjohn UK Ltd) Eplerenone 25 mg Inspra 25mg tablets | 28 tablet P £42.72 DT = £4.43 Eplerenone 50 mg Inspra 50mg tablets | 28 tablet P £42.72 DT = £5.87
Source page 228
Filter the extracted dose blocks for this individual drug.
First line only; read the complete Indications and dose section above.
Initially 25 mg daily, then increased to 50 mg
This is a first-line fragment. Read the full Indications and Dose section above.
Candidate age grouping · source page 227
