Therapeutic Action
Macrolide antibacterial
Source page 132
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Individual generic drug information
Extracted information for ERYTHROMYCIN only.
Macrolide antibacterial
Source page 132
Alternative to first-line antibiotic treatment of: Louse-borne relapsing fever, leptospirosis Acute otitis media, pharyngitis and sinusitis; diphtheria, pertussis, atypical pneumonia due to Mycoplasma pneumoniae or Chlamydophila pneumoniae Leg ulcer Cervicitis and urethritis due to Chlamydia trachomatis (in combination with a treatment for gonorrhoea), donovanosis, chancroid, lymphogranuloma venereum, syphilis Trachoma Neonatal conjunctivitis due to Chlamydia trachomatis Completion treatment following parenteral therapy with erythromycin
Source page 132
Extracted information for ERYTHROMYCIN only.
Do not administer to patients with allergy to erythromycin or another macrolide. Avoid or administer with caution to children under 6 months and particularly to neonates under 2 weeks (risk of hypertrophic pyloric stenosis). Administer with caution to patients with hepatic or renal impairment (max. 1.5 g daily for adult with severe renal impairment), electrolyte disturbances or at increased risk of cardiovascular morbidity. May cause: gastrointestinal disturbances, reversible hearing disorders, heart rhythm disorders (QT prolongation); allergic reactions sometimes severe. In the event of allergic reaction, stop treatment immediately. Avoid combination with drugs that prolong the QT interval (amiodarone, chloroquine, co- artemether, fluconazole, haloperidol, mefloquine, moxifloxacin, ondansetron, pentamidine, quinine, etc.). Administer with caution and monitor use in patients taking carbamazepine, digoxin or warfarin (plasma concentrations of these drugs increased). Pregnancy and breast-feeding: no contra-indication
Source pages 133, 134
Extracted information for ERYTHROMYCIN only.
250 mg and 500 mg tablets 125 mg/5 ml powder for oral suspension: , to be reconstituted with filtered water to be administered using a measuring device (oral syringe, measuring spoon, or cup with graduations)
Source page 132
Louse-borne relapsing fever Child under 5 years: 250 mg single dose Child 5 years and over and adult: 500 mg single dose Diphtheria Child under 40 kg: 10 to 15 mg/kg (max. 500 mg) 4 times daily Child 40 kg and over and adult: 500 mg 4 times daily Neonatal conjunctivitis due to C. trachomatis Other indications Child: 30 to 50 mg/kg daily in divided doses 125 mg/5 ml 250 mg 500 mg Age Weight Daily dose susp. tablet tablet 1 to < 2 months 4 to < 5 kg 62.5 mg x 2 2.5 ml x 2 ¼ tab x 2 − 2 to < 12 months 5 to < 10 kg 125 mg x 2 5 ml x 2 ½ tab x 2 ¼ tab x 2 1 to < 3 years 10 to < 15 kg 250 mg x 2 10 ml x 2 1 tab x 2 ½ tab x 2 3 to < 8 years 15 to < 25 kg 250 mg x 3 10 ml x 3 1 tab x 3 ½ tab x 3 8 to < 11 years 25 to < 35 kg 500 mg x 2 − 2 tab x 2 1 tab x 2 11 to < 13 years 35 to < 45 kg 500 mg x 3 − 2 tab x 3 1 tab x 3 Adult: 500 mg 4 times daily or 1 g 2 to 3 times daily
Source pages 132, 133
Leptospirosis, pertussis, cervicitis and urethritis, chancroid, leg ulcer: 7 days Sinusitis: 7 to 10 days Pharyngitis, otitis: 10 days Atypical pneumonia: 10 to 14 days Diphtheria, early syphilis, lymphogranuloma venereum, donovanosis, conjunctivitis due to C. trachomatis, trachoma: 14 days Late latent syphilis: 30 days
Source page 133
Extracted information for ERYTHROMYCIN only.
Take tablets preferably one hour before or 2 hours after a meal.
Source page 134
– – Below 25 °C For the oral suspension (powder or reconstituted suspension): follow manufacturer’s instructions.
Source page 134
Filter the extracted dose blocks for this individual drug.
250 mg single dose
Candidate age grouping · source page 132
500 mg single dose
Candidate age grouping · source page 132
10 to 15 mg/kg (max. 500 mg) 4 times daily
Candidate age grouping · source page 132
500 mg 4 times daily
Candidate age grouping · source page 132
30 to 50 mg/kg daily in divided doses
Candidate age grouping · source page 133