Individual generic drug information

etoricoxib

Reference monograph

Part of registered formulation

ETORICOXIB

Reference record: Etoricoxib
Source: BNF 80 (2020–2021)
Printed source pages: 1223, 1224
Age groups indexed: 2

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Etoricoxib only.

Indications And Dose

Pain and inflammation in osteoarthritis ▶BY MOUTH ▶Child 16–17 years: 30 mg once daily, increased if necessary to 60 mg once daily ▶Adult: 30 mg once daily, increased if necessary to 60 mg once daily Pain and inflammation in rheumatoid arthritis | Ankylosing spondylitis ▶BY MOUTH ▶Child 16–17 years: 60 mg once daily, increased if necessary to 90 mg once daily ▶Adult: 60 mg once daily, increased if necessary to 90 mg once daily Acute gout ▶BY MOUTH ▶Child 16–17 years: 120 mg once daily for maximum 8 days ▶Adult: 120 mg once daily for maximum 8 days

Source page 1223

Contra Indications

Active gastro-intestinal bleeding. active gastro-intestinal ulceration. cerebrovascular disease. inﬂammatory bowel disease. ischaemic heart disease. mild to severe heart failure. peripheral arterial disease. uncontrolled hypertension (persistently above 140/90 mmHg)

Source page 1223

Cautions

Allergic disorders. cardiac impairment (NSAIDs may impair renal function). coagulation defects. connective-tissue disorders. dehydration (risk of renal impairment). elderly (risk of serious side-effects and fatalities). history of cardiac failure. history of gastro- intestinal disorders. hypertension. left ventricular dysfunction. oedema. risk factors for cardiovascular events

Source pages 1223, 1224

Allergy And Cross Sensitivity

Contra-indicated in patients with a history of hypersensitivity to aspirin or any other NSAID—which includes those in whom attacks of asthma, angioedema, urticaria or rhinitis have been precipitated by aspirin or any other NSAID.

Source page 1224

Safety

Extracted information for Etoricoxib only.

Interactions

→Appendix 1: NSAIDs

Source page 1224

Side Effects

▶Common or very common Arrhythmias. asthenia. bronchospasm. constipation. diarrhoea. dizziness. ﬂuid retention. gastrointestinal discomfort. gastrointestinal disorders. headache. hypertension. increased risk of infection. inﬂuenza like illness. nausea. oedema. oral ulceration. palpitations. skin reactions. vomiting ▶Uncommon Alertness decreased. anaemia. angina pectoris . anxiety. appetite abnormal. cerebrovascular insufﬁciency. chest pain. congestive heart failure. Musculoskeletal system conjunctivitis. cough. depression. drowsiness. dry mouth . dyspnoea. ﬂushing. haemorrhage. hallucination. hyperkalaemia. hypersensitivity. insomnia. irritable bowel syndrome. leucopenia. myocardial infarction. pancreatitis. proteinuria. renal failure (more common in patients with pre-existing renal impairment). sensation abnormal. taste altered. thrombocytopenia. tinnitus. vasculitis. vertigo. vision blurred. weight increased ▶Rare or very rare Angioedema. confusion. hepatic disorders. muscle complaints. severe cutaneous adverse reactions (SCARs). shock ▶Frequency not known Nephritis tubulointerstitial. nephropathy SIDE-EFFECTS, FURTHER INFORMATION For information about cardiovascular and gastrointestinal side-effects, and a possible exacerbation of symptoms in asthma, see Non- steroidal anti-inﬂammatory drugs p. 1193.

Source page 1224

Conception And Contraception

Caution—long-term use of some NSAIDs is associated with reduced female fertility, which is reversible on stopping treatment.

Source page 1224

Pregnancy

Manufacturer advises avoid (teratogenic in animal studies). Avoid during the third trimester (risk of closure of fetal ductus arteriosus in utero and possibly persistent pulmonary hypertension of the newborn); onset of labour may be delayed and duration may be increased.

Source page 1224

Breast Feeding

Use with caution during breast-feeding. Manufacturer advises avoid—present in milk in animal studies.

Source page 1224

Hepatic Impairment

Manufacturer advises caution in mild to moderate impairment; avoid in severe impairment (no information available). Dose adjustments Manufacturer advises max. 60 mg once daily in mild impairment; max. 30 mg once daily in moderate impairment.

Source page 1224

Renal Impairment

Avoid if possible or use with caution. ▶In adults Avoid if eGFR less than 30 mL/minute/1.73 m2. ▶In children Avoid if estimated glomerular ﬁltration rate less than 30 mL/minute/1.73 m2. Dose adjustments The lowest effective dose should be used for the shortest possible duration. Monitoring In renal impairment monitor renal function; sodium and water retention may occur and renal function may deteriorate, possibly leading to renal failure.

Source page 1224

Monitoring Requirements

Monitor blood pressure before treatment, 2 weeks after initiation and periodically during treatment.

Source page 1224

Dose and formulations

Extracted information for Etoricoxib only.

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Tablet ▶Etoricoxib (Non-proprietary) Etoricoxib 30 mg Etoricoxib 30mg tablets | 28 tablet P £13.99 DT = £8.18 Etoricoxib 60 mg Etoricoxib 60mg tablets | 28 tablet P £20.11 DT = £2.79 Etoricoxib 90 mg Etoricoxib 90mg tablets | 28 tablet P £22.96 DT = £2.89 Etoricoxib 120 mg Etoricoxib 120mg tablets | 7 tablet P £1.90– £5.73 | 28 tablet P £24.11 DT = £13.71 ▶Arcoxia (Merck Sharp & Dohme Ltd) Etoricoxib 30 mg Arcoxia 30mg tablets | 28 tablet P £13.99 DT = £8.18 Etoricoxib 60 mg Arcoxia 60mg tablets | 28 tablet P £20.11 DT = £2.79 Etoricoxib 90 mg Arcoxia 90mg tablets | 28 tablet P £22.96 DT = £2.89 Etoricoxib 120 mg Arcoxia 120mg tablets | 7 tablet P £6.03 | 28 tablet P £24.11 DT = £13.71

Source page 1224

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Children

First line only; read the complete Indications and dose section above.

30 mg once daily, increased if

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 1223

Children

First line only; read the complete Indications and dose section above.

60 mg once daily, increased if

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 1223

Children

First line only; read the complete Indications and dose section above.

120 mg once daily for maximum

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 1223

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.

Individual generic drug information

etoricoxib

Reference monograph

Part of registered formulation

ETORICOXIB

Reference record: Etoricoxib
Source: BNF 80 (2020–2021)
Printed source pages: 1223, 1224
Age groups indexed: 2

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Etoricoxib only.

Indications And Dose

Source page 1223

Contra Indications

Source page 1223

Cautions

Source pages 1223, 1224

Allergy And Cross Sensitivity

Source page 1224

Safety

Extracted information for Etoricoxib only.

Interactions

→Appendix 1: NSAIDs

Source page 1224

Side Effects

Source page 1224

Conception And Contraception

Caution—long-term use of some NSAIDs is associated with reduced female fertility, which is reversible on stopping treatment.

Source page 1224

Pregnancy

Source page 1224

Breast Feeding

Use with caution during breast-feeding. Manufacturer advises avoid—present in milk in animal studies.

Source page 1224

Hepatic Impairment

Source page 1224

Renal Impairment

Source page 1224

Monitoring Requirements

Monitor blood pressure before treatment, 2 weeks after initiation and periodically during treatment.

Source page 1224

Dose and formulations

Extracted information for Etoricoxib only.

Medicinal Forms

Source page 1224

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Children

First line only; read the complete Indications and dose section above.

30 mg once daily, increased if

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 1223

Children

First line only; read the complete Indications and dose section above.

60 mg once daily, increased if

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 1223

Children

First line only; read the complete Indications and dose section above.

120 mg once daily for maximum

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 1223

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.