Individual generic drug information

famciclovir

Reference monograph

Part of registered formulation

FAMCICLOVIR

Reference record: Famciclovir
Source: BNF 80 (2020–2021)
Printed source pages: 694, 695
Age groups indexed: 1

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Famciclovir only.

Indications And Dose

Herpes zoster infection, treatment ▶BY MOUTH ▶Adult: 500 mg 3 times a day for 7 days, alternatively 750 mg 1–2 times a day for 7 days Herpes zoster infection, treatment in immunocompromised patients ▶BY MOUTH ▶Adult: 500 mg 3 times a day for 10 days, continue for 2 days after crusting of lesions Genital herpes, suppression ▶BY MOUTH ▶Adult: 250 mg twice daily, therapy to be interrupted every 6–12 months to reassess recurrence frequency— consider restarting after two or more recurrences Genital herpes, suppression in immunocompromised or HIV-positive patients ▶BY MOUTH ▶Adult: 500 mg twice daily, therapy to be interrupted every 6–12 months to reassess recurrence frequency— consider restarting after two or more recurrences Genital herpes infection, treatment of first episode ▶BY MOUTH ▶Adult: 250 mg 3 times a day for 5 days or longer if new lesions appear during treatment or if healing incomplete Genital herpes infection, treatment of first episode in immunocompromised or HIV-positive patients ▶BY MOUTH ▶Adult: 500 mg twice daily for 10 days Genital herpes infection, treatment of recurrent infection ▶BY MOUTH ▶Adult: 125 mg twice daily for 5 days, alternatively 1 g twice daily for 1 day Genital herpes infection, treatment of recurrent infections in immunocompromised or HIV-positive patients ▶BY MOUTH ▶Adult: 500 mg twice daily for 5–10 days Herpes simplex infection (non-genital), treatment in immunocompromised patients ▶BY MOUTH ▶Adult: 500 mg twice daily for 7 days l UNLICENSED USE Famciclovir doses in BNF may differ from those in product literature.

Source page 694

Prescribing And Dispensing Information

Famciclovir is a pro-drug of penciclovir.

Source page 694

Safety

Extracted information for Famciclovir only.

Side Effects

▶Common or very common Abdominal pain. diarrhoea. dizziness. headache. nausea. skin reactions. vomiting ▶Uncommon Angioedema. confusion. drowsiness ▶Rare or very rare Hallucination. jaundice cholestatic. palpitations. thrombocytopenia

Source page 694

Pregnancy

Manufacturers advise avoid unless potential beneﬁt outweighs risk.

Source page 694

Breast Feeding

No information available—present in milk in animal studies.

Source page 694

Hepatic Impairment

Manufacturer advises efﬁcacy may be decreased in severe impairment (risk of impaired conversion to active metabolite, no information available).

Source page 694

Renal Impairment

Dose adjustments Reduce dose; consult product literature.

Source page 694

Dose and formulations

Extracted information for Famciclovir only.

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: tablet Tablet CAUTIONARY AND ADVISORY LABELS 9 ▶Famciclovir (Non-proprietary) Famciclovir 125 mg Famciclovir 125mg tablets | 10 tablet P £65.42 DT = £65.42 Famciclovir 250 mg Famciclovir 250mg tablets | 15 tablet P £110.59–£132.80 | 21 tablet P £184.50 DT = £183.28 | 56 tablet P £412.85–£495.78 Famciclovir 500 mg Famciclovir 500mg tablets | 14 tablet P £190.16 DT = £188.87 ▶Famvir (Phoenix Labs Ltd) Famciclovir 125 mg Famvir 125mg tablets | 10 tablet P £53.45 DT = £65.42 Famciclovir 250 mg Famvir 250mg tablets | 15 tablet P £160.34 | 56 tablet P £598.56 Famciclovir 500 mg Famvir 500mg tablets | 30 tablet P £641.21

Source pages 694, 695

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

500 mg 3 times a day for 7 days, alternatively

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 694

Adults

First line only; read the complete Indications and dose section above.

500 mg 3 times a day for 10 days, continue for

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 694

Adults

First line only; read the complete Indications and dose section above.

250 mg twice daily, therapy to be interrupted

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 694

Adults

First line only; read the complete Indications and dose section above.

500 mg twice daily, therapy to be interrupted

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 694

Adults

First line only; read the complete Indications and dose section above.

250 mg 3 times a day for 5 days or longer if new

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 694

Adults

First line only; read the complete Indications and dose section above.

500 mg twice daily for 10 days

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 694

Adults

First line only; read the complete Indications and dose section above.

125 mg twice daily for 5 days, alternatively 1 g

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 694

Adults

First line only; read the complete Indications and dose section above.

500 mg twice daily for 5–10 days

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 694

Adults

First line only; read the complete Indications and dose section above.

500 mg twice daily for 7 days

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 694

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.

Individual generic drug information

famciclovir

Reference monograph

Part of registered formulation

FAMCICLOVIR

Reference record: Famciclovir
Source: BNF 80 (2020–2021)
Printed source pages: 694, 695
Age groups indexed: 1

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Famciclovir only.

Indications And Dose

Source page 694

Prescribing And Dispensing Information

Famciclovir is a pro-drug of penciclovir.

Source page 694

Safety

Extracted information for Famciclovir only.

Side Effects

Source page 694

Pregnancy

Manufacturers advise avoid unless potential beneﬁt outweighs risk.

Source page 694

Breast Feeding

No information available—present in milk in animal studies.

Source page 694

Hepatic Impairment

Manufacturer advises efﬁcacy may be decreased in severe impairment (risk of impaired conversion to active metabolite, no information available).

Source page 694

Renal Impairment

Dose adjustments Reduce dose; consult product literature.

Source page 694

Dose and formulations

Extracted information for Famciclovir only.

Medicinal Forms

Source pages 694, 695

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

500 mg 3 times a day for 7 days, alternatively

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 694

Adults

First line only; read the complete Indications and dose section above.

500 mg 3 times a day for 10 days, continue for

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 694

Adults

First line only; read the complete Indications and dose section above.

250 mg twice daily, therapy to be interrupted

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 694

Adults

First line only; read the complete Indications and dose section above.

500 mg twice daily, therapy to be interrupted

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 694

Adults

First line only; read the complete Indications and dose section above.

250 mg 3 times a day for 5 days or longer if new

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 694

Adults

First line only; read the complete Indications and dose section above.

500 mg twice daily for 10 days

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 694

Adults

First line only; read the complete Indications and dose section above.

125 mg twice daily for 5 days, alternatively 1 g

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 694

Adults

First line only; read the complete Indications and dose section above.

500 mg twice daily for 5–10 days

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 694

Adults

First line only; read the complete Indications and dose section above.

500 mg twice daily for 7 days

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 694

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.