Indications And Dose
Major depression ▶BY MOUTH ▶Adult: Initially 20 mg daily, dose is increased after 3–4 weeks if necessary, and at appropriate intervals thereafter, daily dose may be administered as a single or divided dose; maximum 60 mg per day ▶Elderly: Initially 20 mg daily, dose is increased after 3–4 weeks if necessary, and at appropriate intervals thereafter, daily dose may be administered as a single or divided dose, usual maximum dose is 40 mg daily but doses up to 60 mg daily can be used Bulimia nervosa ▶BY MOUTH ▶Adult: 60 mg daily, daily dose may be administered as a single or divided dose ▶Elderly: Up to 40 mg daily, daily dose may be administered as a single or divided dose, usual maximum dose is 40 mg daily but doses up to 60 mg daily can be used Obsessive-compulsive disorder ▶BY MOUTH ▶Adult: 20 mg daily, increased if necessary up to 60 mg daily, daily dose may be administered as a single or divided dose, dose to be increased gradually, review treatment if inadequate response after 10 weeks; maximum 60 mg per day Nervous system ▶Elderly: 20 mg daily, increased if necessary up to 40 mg daily, daily dose may be administered as a single or divided dose, dose to be increased gradually, review treatment if inadequate response after 10 weeks, usual maximum dose is 40 mg daily but doses up to 60 mg daily can be used Menopausal symptoms, particularly hot flushes, in women with breast cancer (except those taking tamoxifen) ▶BY MOUTH ▶Adult: 20 mg once daily
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