Individual generic drug information

furosemide

Reference monograph

Part of registered formulation

FUROSEMIDE

Reference record: Furosemide
Source: BNF 80 (2020–2021)
Printed source pages: 263, 264
Age groups indexed: 1

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Furosemide only.

Indications And Dose

Oedema ▶BY MOUTH ▶Adult: Initially 40 mg daily, dose to be taken in the morning, then maintenance 20–40 mg daily ▶INITIALLY BY INTRAMUSCULAR INJECTION, OR BY SLOW INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult: Initially 20–50 mg, then (by intramuscular injection or by intravenous injection or by intravenous infusion) increased in steps of 20 mg every 2 hours if required, doses greater than 50 mg given by intravenous infusion only; maximum 1.5 g per day Resistant oedema ▶BY MOUTH ▶Adult: 80–120 mg daily ▶INITIALLY BY INTRAMUSCULAR INJECTION, OR BY SLOW INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult: Initially 20–50 mg, then (by intramuscular injection or by intravenous injection or by intravenous infusion) increased in steps of 20 mg every 2 hours if required, doses greater than 50 mg given by intravenous infusion only; maximum 1.5 g per day Resistant hypertension ▶BY MOUTH ▶Adult: 40–80 mg daily ▶INITIALLY BY INTRAMUSCULAR INJECTION, OR BY SLOW INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult: Initially 20–50 mg, then (by intramuscular injection or by intravenous injection or by intravenous infusion) increased in steps of 20 mg every 2 hours if required, doses greater than 50 mg given by intravenous infusion only; maximum 1.5 g per day

Source page 263

Cautions

Hepatorenal syndrome. hypoproteinaemia may reduce diuretic effect and increase risk of side-effects

Source page 263

Safety

Extracted information for Furosemide only.

Interactions

→Appendix 1: loop diuretics

Source page 263

Side Effects

GENERAL SIDE-EFFECTS Agranulocytosis. aplastic anaemia. auditory disorder (more common with rapid intravenous administration, and in renal impairment). diabetes mellitus. eosinophilia. fever. gout. haemolytic anaemia. hepatic encephalopathy . malaise. mucosal reaction. nephritis tubulointerstitial. pancreatitis acute. shock. skin eruption. tetany. vasculitis SPECIFIC SIDE-EFFECTS ▶With oral use Acute kidney injury. hepatic disorders. Cardiovascular system metabolic acidosis. psychiatric disorder. urinary disorders ▶With parenteral use Acute urinary retention. cholestasis

Source pages 263, 264

Pregnancy

Furosemide should not be used to treat gestational hypertension because of the maternal hypovolaemia associated with this condition.

Source page 264

Breast Feeding

Amount too small to be harmful. May inhibit lactation.

Source page 264

Dose and formulations

Extracted information for Furosemide only.

Directions For Administration

Intravenous administration rate should not usually exceed 4 mg/minute however single doses of up to 80 mg may be administered more rapidly; a lower rate of infusion may be necessary in renal impairment. For intravenous infusion (Lasix ®), give continuously in Sodium chloride 0.9%; infusion pH must be above 5.5; glucose solutions are unsuitable.

Source page 264

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral suspension, oral solution Tablet ▶Furosemide (Non-proprietary) Furosemide 20 mg Furosemide 20mg tablets | 28 tablet P £5.69 DT = £0.77 | 250 tablet P £5.08–£6.88 Furosemide 40 mg Furosemide 40mg tablets | 28 tablet P £7.55 DT = £0.80 | 250 tablet P £3.50–£7.14 | 1000 tablet P £28.21–£48.77 Furosemide 500 mg Furosemide 500mg tablets | 28 tablet P £39.02 DT = £39.02 ▶Diuresal (Ennogen Pharma Ltd) Furosemide 500 mg Diuresal 500mg tablets | 28 tablet P £39.02 DT = £39.02 Solution for injection ▶Furosemide (Non-proprietary) Furosemide 10 mg per 1 ml Furosemide 250mg/25ml solution for injection ampoules | 10 ampoule P £30.00–£40.00 Furosemide 50mg/5ml solution for injection ampoules | 10 ampoule P £9.00–£50.00 | 10 ampoule P £2.38 (Hospital only) Furosemide 20mg/2ml solution for injection ampoules | 10 ampoule P £4.58 DT = £21.19 (Hospital only) | 10 ampoule P £3.50–£40.00 DT = £21.19 Oral solution EXCIPIENTS: May contain Alcohol ▶Furosemide (Non-proprietary) Furosemide 4 mg per 1 ml Furosemide 20mg/5ml oral solution sugar-free | 150 ml P £14.81 DT = £14.81 Furosemide 8 mg per 1 ml Furosemide 40mg/5ml oral solution sugar-free | 150 ml P £19.53 DT = £19.53 Furosemide 10 mg per 1 ml Furosemide 50mg/5ml oral solution sugar-free | 150 ml P £20.21 DT = £20.21 ▶Frusol (Rosemont Pharmaceuticals Ltd) Furosemide 4 mg per 1 ml Frusol 20mg/5ml oral solution sugar-free | 150 ml P £12.07 DT = £14.81 Furosemide 8 mg per 1 ml Frusol 40mg/5ml oral solution sugar-free | 150 ml P £15.58 DT = £19.53 Furosemide 10 mg per 1 ml Frusol 50mg/5ml oral solution sugar- free | 150 ml P £16.84 DT = £20.21 Combinations available: Spironolactone with furosemide, p. 243

Source page 264

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

Initially 40 mg daily, dose to be taken in the

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 263

Adults

First line only; read the complete Indications and dose section above.

Initially 20–50 mg, then (by intramuscular

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 263

Adults

First line only; read the complete Indications and dose section above.

80–120 mg daily

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 263

Adults

First line only; read the complete Indications and dose section above.

Initially 20–50 mg, then (by intramuscular

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 263

Adults

First line only; read the complete Indications and dose section above.

40–80 mg daily

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 263

Adults

First line only; read the complete Indications and dose section above.

Initially 20–50 mg, then (by intramuscular

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 263

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.

Individual generic drug information

furosemide

Reference monograph

Part of registered formulation

FUROSEMIDE

Reference record: Furosemide
Source: BNF 80 (2020–2021)
Printed source pages: 263, 264
Age groups indexed: 1

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Furosemide only.

Indications And Dose

Source page 263

Cautions

Hepatorenal syndrome. hypoproteinaemia may reduce diuretic effect and increase risk of side-effects

Source page 263

Safety

Extracted information for Furosemide only.

Interactions

→Appendix 1: loop diuretics

Source page 263

Side Effects

Source pages 263, 264

Pregnancy

Furosemide should not be used to treat gestational hypertension because of the maternal hypovolaemia associated with this condition.

Source page 264

Breast Feeding

Amount too small to be harmful. May inhibit lactation.

Source page 264

Dose and formulations

Extracted information for Furosemide only.

Directions For Administration

Source page 264

Medicinal Forms

Source page 264

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

Initially 40 mg daily, dose to be taken in the

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 263

Adults

First line only; read the complete Indications and dose section above.

Initially 20–50 mg, then (by intramuscular

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 263

Adults

First line only; read the complete Indications and dose section above.

80–120 mg daily

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 263

Adults

First line only; read the complete Indications and dose section above.

Initially 20–50 mg, then (by intramuscular

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 263

Adults

First line only; read the complete Indications and dose section above.

40–80 mg daily

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 263

Adults

First line only; read the complete Indications and dose section above.

Initially 20–50 mg, then (by intramuscular

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 263

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.