Indications And Dose
Adjunctive treatment of focal seizures with or without secondary generalisation ▶BY MOUTH ▶Child 6–11 years: 10 mg/kg once daily (max. per dose 300 mg) on day 1, then 10 mg/kg twice daily (max. per dose 300 mg) on day 2, then 10 mg/kg 3 times a day (max. per dose 300 mg) on day 3; usual dose 25–35 mg/kg daily in 3 divided doses, some children may not tolerate daily increments; longer intervals (up to weekly) may be more appropriate, daily dose maximum to be given in 3 divided doses; maximum 70 mg/kg per day ▶Child 12–17 years: Initially 300 mg once daily on day 1, then 300 mg twice daily on day 2, then 300 mg 3 times a day on day 3, alternatively initially 300 mg 3 times a day on day 1, then increased in steps of 300 mg every 2–3 days in 3 divided doses, adjusted according to response; usual dose 0.9–3.6 g daily in 3 divided doses (max. per dose 1.6 g 3 times a day), some children may not tolerate daily increments; longer intervals (up to weekly) may be more appropriate ▶Adult: Initially 300 mg once daily on day 1, then 300 mg twice daily on day 2, then 300 mg 3 times a day on day 3, alternatively initially 300 mg 3 times a day on day 1, then increased in steps of 300 mg every 2–3 days in 3 divided doses, adjusted according to response; usual dose 0.9–3.6 g daily in 3 divided doses (max. per dose 1.6 g 3 times a day) Monotherapy for focal seizures with or without secondary generalisation ▶BY MOUTH ▶Child 12–17 years: Initially 300 mg once daily on day 1, then 300 mg twice daily on day 2, then 300 mg 3 times a day on day 3, alternatively initially 300 mg 3 times a day on day 1, then increased in steps of 300 mg every 2–3 days in 3 divided doses, adjusted according to response; usual dose 0.9–3.6 g daily in 3 divided doses (max. per dose 1.6 g 3 times a day), some children may not tolerate daily increments; longer intervals (up to weekly) may be more appropriate ▶Adult: Initially 300 mg once daily on day 1, then 300 mg twice daily on day 2, then 300 mg 3 times a day on day 3, alternatively initially 300 mg 3 times a day on day 1, then increased in steps of 300 mg every 2–3 days in 3 divided doses, adjusted according to response; usual dose 0.9–3.6 g daily in 3 divided doses (max. per dose 1.6 g 3 times a day) Peripheral neuropathic pain ▶BY MOUTH ▶Adult: Initially 300 mg once daily on day 1, then 300 mg twice daily on day 2, then 300 mg 3 times a day on day 3, alternatively initially 300 mg 3 times a day on day 1, then increased in steps of 300 mg every 2–3 days in 3 divided doses, adjusted according to response; continued → maximum 3.6 g per day Menopausal symptoms, particularly hot flushes, in women with breast cancer ▶BY MOUTH ▶Adult: 300 mg 3 times a day, initial dose should be lower and titrated up over three days Oscillopsia in multiple sclerosis ▶BY MOUTH Nervous system ▶Adult: Initially 300 mg once daily, then increased in steps of 300 mg, every 4–7 days, adjusted according to response; usual maximum 900 mg 3 times a day Spasticity in multiple sclerosis ▶BY MOUTH ▶Adult: Initially 300 mg once daily for 1–2 weeks, then 300 mg twice daily for 1–2 weeks, then 300 mg 3 times a day for 1–2 weeks, alternatively initially 100 mg 3 times a day, then increased in steps of 100 mg 3 times a day, every 1–2 weeks, adjusted according to response; usual maximum 900 mg 3 times a day l UNLICENSED USE ▶In children Not licensed at doses over 50 mg/kg daily in children under 12 years. ▶In adults g Gabapentin is used for the treatment of menopausal symptoms, h but is not licensed for this indication. g Gabapentin is used for oscillopsia in multiple sclerosis, l but is not licensed for this indication. g Gabapentin is used for spasticity in multiple sclerosis, l but is not licensed for this indication.
Source pages 353, 354