Individual generic drug information

lactulose

Reference monograph

Part of registered formulation

LACTULOSE

Reference record: Lactulose
Source: BNF 80 (2020–2021)
Printed source pages: 82
Age groups indexed: 2

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Lactulose only.

Indications And Dose

Constipation ▶BY MOUTH ▶Child 1–11 months: 2.5 mL twice daily, adjusted according to response ▶Child 1–4 years: 2.5–10 mL twice daily, adjusted according to response ▶Child 5–17 years: 5–20 mL twice daily, adjusted according to response ▶Adult: Initially 15 mL twice daily, adjusted according to response Hepatic encephalopathy (portal systemic encephalopathy) ▶BY MOUTH ▶Adult: Adjusted according to response to 30–50 mL 3 times a day, subsequently adjusted to produce 2–3 soft stools per day Constipation (dose approved for use by community practitioner nurse prescribers) ▶BY MOUTH ▶Child 1–11 months: 2.5 mL twice daily, adjusted according to response ▶Child 1–4 years: 5 mL twice daily, adjusted according to response ▶Child 5–10 years: 10 mL twice daily, adjusted according to response ▶Child 11–17 years: Initially 15 mL twice daily, adjusted according to response ▶Adult: Initially 15 mL twice daily, adjusted according to response

Source page 82

Pharmacokinetics

▶Lactulose may take up to 48 hours to act. l UNLICENSED USE ▶In adults Lactulose doses in the BNF may differ from those in product literature.

Source page 82

Contra Indications

Galactosaemia. gastro-intestinal obstruction. gastro-intestinal perforation. risk of gastro- intestinal perforation

Source page 82

Cautions

Lactose intolerance

Source page 82

Safety

Extracted information for Lactulose only.

Side Effects

▶Common or very common Abdominal pain. diarrhoea. ﬂatulence. nausea. vomiting ▶Uncommon Electrolyte imbalance

Source page 82

Pregnancy

Not known to be harmful.

Source page 82

Dose and formulations

Extracted information for Lactulose only.

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Oral solution ▶Lactulose (Non-proprietary) Lactulose 666.667 mg per 1 ml Lactulose 10g/15ml oral solution 15ml sachets sugar free sugar-free | 10 sachet p £2.51 DT = £2.51 Lactulose 10g/15ml oral solution 15ml sachets sugar free unflavoured sugar-free | 10 sachet p £2.50 DT = £2.51 Lactulose 10g/15ml oral solution 15ml sachets sugar free plum sugar- free | 10 sachet p £2.60 DT = £2.51 Lactulose 680 mg per 1 ml Lactulose 3.1-3.7g/5ml oral solution | 300 ml p £1.37–£5.50 | 500 ml p £6.50 DT = £2.90 ▶Duphalac (Mylan) Lactulose 680 mg per 1 ml Duphalac 3.35g/5ml oral solution | 200 ml p £1.92 | 300 ml p £2.88 | 500 ml p £4.80 DT = £2.90

Source page 82

Clinical care

Extracted information for Lactulose only.

Patient And Carer Advice

Medicines for Children leaflet: Lactulose for constipation www.medicinesforchildren.org.uk/lactulose-constipation

Source page 82

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Children

First line only; read the complete Indications and dose section above.

2.5 mL twice daily, adjusted

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 82

Children

First line only; read the complete Indications and dose section above.

2.5–10 mL twice daily, adjusted

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 82

Children

First line only; read the complete Indications and dose section above.

5–20 mL twice daily, adjusted

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 82

Children

First line only; read the complete Indications and dose section above.

2.5 mL twice daily, adjusted

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 82

Children

First line only; read the complete Indications and dose section above.

5 mL twice daily, adjusted according to

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 82

Children

First line only; read the complete Indications and dose section above.

10 mL twice daily, adjusted according

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 82

Children

First line only; read the complete Indications and dose section above.

Initially 15 mL twice daily, adjusted

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 82

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.

Individual generic drug information

lactulose

Reference monograph

Part of registered formulation

LACTULOSE

Reference record: Lactulose
Source: BNF 80 (2020–2021)
Printed source pages: 82
Age groups indexed: 2

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Lactulose only.

Indications And Dose

Source page 82

Pharmacokinetics

▶Lactulose may take up to 48 hours to act. l UNLICENSED USE ▶In adults Lactulose doses in the BNF may differ from those in product literature.

Source page 82

Contra Indications

Galactosaemia. gastro-intestinal obstruction. gastro-intestinal perforation. risk of gastro- intestinal perforation

Source page 82

Cautions

Lactose intolerance

Source page 82

Safety

Extracted information for Lactulose only.

Side Effects

▶Common or very common Abdominal pain. diarrhoea. ﬂatulence. nausea. vomiting ▶Uncommon Electrolyte imbalance

Source page 82

Pregnancy

Not known to be harmful.

Source page 82

Dose and formulations

Extracted information for Lactulose only.

Medicinal Forms

Source page 82

Clinical care

Extracted information for Lactulose only.

Patient And Carer Advice

Medicines for Children leaflet: Lactulose for constipation www.medicinesforchildren.org.uk/lactulose-constipation

Source page 82

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Children

First line only; read the complete Indications and dose section above.

2.5 mL twice daily, adjusted

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 82

Children

First line only; read the complete Indications and dose section above.

2.5–10 mL twice daily, adjusted

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 82

Children

First line only; read the complete Indications and dose section above.

5–20 mL twice daily, adjusted

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 82

Children

First line only; read the complete Indications and dose section above.

2.5 mL twice daily, adjusted

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 82

Children

First line only; read the complete Indications and dose section above.

5 mL twice daily, adjusted according to

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 82

Children

First line only; read the complete Indications and dose section above.

10 mL twice daily, adjusted according

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 82

Children

First line only; read the complete Indications and dose section above.

Initially 15 mL twice daily, adjusted

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 82

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.