Therapeutic Action
Antiseizure (antiepileptic)
Source page 191
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Individual generic drug information
Extracted information for LEVETIRACETAM only.
Antiseizure (antiepileptic)
Source page 191
Epilepsy: generalised tonic-clonic seizures, focal (partial) seizures and absence seizures
Source page 191
Extracted information for LEVETIRACETAM only.
Administer with caution to patients with renal impairment (reduce dosage) or heart disorders. May cause: drowsiness (caution when driving/operating machinery), headache, asthenia, dizziness, mood and behavioural disturbances, anxiety, depression, insomnia; haematologic disorders, gastrointestinal disturbances, cough, nasopharyngitis; rarely: QT prolongation, hypersensitivity reactions (including severe cutaneous reactions such as Stevens-Johnson, Lyell and DRESS syndromes). In these cases stop treatment. Early symptoms such as fever, rash, mouth ulcers and bleeding require immediate medical attention. respiratory depression and coma in the event of overdose. Avoid or monitor the combination with: mefloquine (reduced effect of LEV); drugs that prolong the QT interval (antimalarials, antipsychotics, fluconazole, fluoroquinolones, hydroxyzine, macrolides, ondansetron, etc.); drugs containing alcohol, benzodiazepines, opioid analgesics, antipsychotics, first-generation antihistamines (hydroxyzine, promethazine), antidepressants, other antiseizure medications, etc. (increased sedation). Avoid alcohol during treatment (increased risk of adverse effects). Pregnancy: use the lowest effective dose. Administer folic acid high dose (5 mg daily) during the first trimester. Start as soon as possible, including during the preconception period in case of planned pregnancy. Plasma concentrations may decrease during pregnancy. Monitor clinical response; increase dose if needed then resume the usual dose after delivery. Breast-feeding: administer with caution (excreted in milk); reduce the dose if increased during pregnancy and monitor the child (risk of drowsiness and poor feeding).
Source page 192
Extracted information for LEVETIRACETAM only.
250 mg, 500 mg, 750 mg and 1 g tablets 500 mg/5 ml oral solution, to be administered using a measuring device (oral syringe, measuring spoon, or cup with graduations)
Source page 191
Start with a low dose then increase gradually based on patient's response and tolerance. Child 1 to 5 months: start with 7 mg/kg once daily; increase to 7 mg/kg 2 times daily after 2 weeks, then by increments of 7 mg/kg 2 times daily every 2 weeks if necessary (max. 21 mg/kg 2 times daily). Child 6 months to 17 years (< 50 kg): start with 10 mg/kg once daily; increase to 10 mg/kg 2 times daily after 2 weeks, then by increments of 10 mg/kg 2 times daily every 2 weeks if necessary (max. 30 mg/kg 2 times daily). Child 50 kg and over and adult: start with 250 mg 2 times daily; increase to 500 mg 2 times daily after 2 to 4 weeks, then by increments of 500 mg 2 times daily every 2 to 4 weeks if necessary (max. 1.5 g 2 times daily).
Source page 191
As long as required. Do not stop treatment abruptly, even if changing treatment to another antiseizure medication.
Source page 191
Extracted information for LEVETIRACETAM only.
LEV can be used with contraceptive implants and oral contraceptives.
Source page 192
– Below 25 °C
Source page 192
Filter the extracted dose blocks for this individual drug.
start with 7 mg/kg once daily; increase to 7 mg/kg 2 times daily after 2 weeks, then by increments of 7 mg/kg 2 times daily every 2 weeks if necessary (max. 21 mg/kg 2 times daily).
Candidate age grouping · source page 191
start with 10 mg/kg once daily; increase to 10 mg/kg 2 times daily after 2 weeks, then by increments of 10 mg/kg 2 times daily every 2 weeks if necessary (max.
Candidate age grouping · source page 191
start with 250 mg 2 times daily; increase to 500 mg 2 times daily after 2 to 4 weeks, then by increments of 500 mg 2 times daily every 2 to 4 weeks if necessary (max. 1.5 g 2 times daily).
Candidate age grouping · source page 191