Names and pronunciation
(lee-voh-se-teer′ah-zeen) Children’s Xyzal Allergy 24 HR, Xyzal Allergy 24 HR
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Individual generic drug information
Extracted information for levocetirizine only.
(lee-voh-se-teer′ah-zeen) Children’s Xyzal Allergy 24 HR, Xyzal Allergy 24 HR
Source page 774
Func. class.: Antihistamine, low sedating
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Chem. class.: H1 histamine blocker
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ACTION: Acts on blood vessels, GI, respiratory system by competing with his- tamine for H1-receptor site; decreases allergic response by blocking pharmaco- logic effects of histamine; minimal anti- cholinergic action
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USES: Perennial or seasonal rhinitis, allergy symptoms, chronic idiopathic urticaria
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Extracted information for levocetirizine only.
CONTRAINDICATIONS: Breast- feeding; children 6-11 yr with renal dis- ease; end-stage renal disease; dialysis; hypersensitivity to this product, cetiri- zine, hydrOXYzine Precautions: Pregnancy, driving, renal disease
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SIDE EFFECTS CNS: Drowsiness, fatigue, asthenia, dizziness GI: Dry mouth, increased LFTs, hepatitis MISC: Urinary retention
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INTERACTIONS Increase: CNS depression—alcohol, other CNS depressants Increase: anticholinergic/sedative effect— MAOIs, phenothiazines, tricyclics Decrease: clearance of levocetirizine— ritonavir Drug/Lab Test False negative: skin allergy tests
Source page 775
Extracted information for levocetirizine only.
DOSAGE AND ROUTES • Adult and child ≥12 yr: PO 2.5-5 mg/ day in the evening • Child 6-11 yr: PO (oral solution) 2.5 mg/day in the evening • Child 2-5 yr: PO (oral solution) 1.25 mg/day in the evening • Geriatric: PO 2.5-5 mg/day in the evening Renal dose • Adult: PO CCr 50-80 mL/min, 2.5 mg/ day; CCr 30-49 mL/min, 2.5 mg every other day; CCr 10-29 mL/min, 2.5 mg 2×/ wk; CCr <10 mL/min, do not use
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Available forms: Tabs 5 mg; oral sol 2.5 mg/5 mL
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Administer: • Without regard to meals in the evening; tabs scored, may be broken in half • Store in tight, light-resistant container
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Extracted information for levocetirizine only.
Assess: • Allergy symptoms: pruritus, urticaria, watering eyes at baseline, during treatment • Respiratory status: rate, rhythm, in- crease in bronchial secretions, wheezing, chest tightness • Liver function tests, serum creatinine, BUN • Pregnancy/breastfeeding: use only if clearly needed; do not breastfeed, ex creted in breast milk
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Evaluate: • Therapeutic response: absence of run- ning or congested nose or rashes
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CLINICAL CONSIDERATIONS
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Patient and caregiver information: • About all aspects of product use; to notify prescriber if confusion, sedation, hypotension occur, not to exceed recom- mended dose • To avoid driving, other hazardous ac- tivities if drowsiness occurs • To avoid alcohol, other CNS depressants • Do not breastfeed
Source page 775
Extracted information for levocetirizine only.
PHARMACOKINETICS Rapid absorption; peak 0.9 hr; protein binding 91%-92%; half-life 8 hr; excreted in urine 85.4%, feces 12.9%
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Filter the extracted dose blocks for this individual drug.
• Geriatric: PO 2.5-5 mg/day in the evening Renal dose
Candidate age grouping · source pages 774, 775