Indications And Dose
Severe acute asthma | Continuing respiratory deterioration in anaphylaxis ▶BY INTRAVENOUS INFUSION ▶Child 2–17 years: 40 mg/kg (max. per dose 2 g), to be given over 20 minutes ▶Adult: 1.2–2 g, to be given over 20 minutes Prevention of seizures in pre-eclampsia ▶INITIALLY BY INTRAVENOUS INJECTION ▶Adult: Initially 4 g, to be given over 5–15 minutes, followed by (by intravenous infusion) 1 gram/hour for 24 hours, if seizure occurs, give an additional dose of 2–4 g by intravenous injection over 5–15 minutes Treatment of seizures and prevention of seizure recurrence in eclampsia ▶INITIALLY BY INTRAVENOUS INJECTION ▶Adult: Initially 4 g, to be given over 5–15 minutes, followed by (by intravenous infusion) 1 gram/hour for 24 hours after seizure or delivery (whichever is later), if seizure recurs, give an additional dose of 2–4 g by intravenous injection over 5–15 minutes Hypomagnesaemia ▶BY INTRAVENOUS INFUSION, OR BY INTRAMUSCULAR INJECTION ▶Adult: Up to 40 g, given over a period of up to 5 days, dose given depends on the amount required to replace the deficit (allowing for urinary losses) Hypomagnesaemia maintenance (e.g. in intravenous nutrition) ▶BY INTRAVENOUS INFUSION, OR BY INTRAMUSCULAR INJECTION ▶Adult: 2.5–5 g daily, usual dose 3 g daily Emergency treatment of serious arrhythmias ▶BY INTRAVENOUS INJECTION ▶Adult: 2 g, to be given over 10-15 minutes, dose may be repeated once if necessary Rapid bowel evacuation (acts in 2–4 hours) ▶BY MOUTH ▶Adult: 5–10 g, dose to be mixed in a glass of water, taken preferably before breakfast DOSE EQUIVALENCE AND CONVERSION ▶Magnesium sulfate heptahydrate 1 g equivalent to Mg2+ approx. 4 mmol. l UNLICENSED USE Unlicensed indication in severe acute asthma and continuing respiratory deterioration in anaphylaxis.
Source pages 1134, 1135