Individual generic drug information

moxifloxacin

Reference monograph

Part of registered formulation

MOXIFLOXACIN HYDROCHLORIDE

Reference record: Moxifloxacin
Source: BNF 80 (2020–2021)
Printed source pages: 615
Age groups indexed: 1

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Moxifloxacin only.

Indications And Dose

Sinusitis ▶BY MOUTH ▶Adult: 400 mg once daily for 7 days Community-acquired pneumonia ▶BY MOUTH ▶Adult: 400 mg once daily for 7–14 days ▶BY INTRAVENOUS INFUSION ▶Adult: 400 mg once daily for 7–14 days, to be given over 60 minutes Exacerbations of chronic bronchitis ▶BY MOUTH ▶Adult: 400 mg once daily for 5–10 days Mild to moderate pelvic inflammatory disease ▶BY MOUTH ▶Adult: 400 mg once daily for 14 days Complicated skin and soft-tissue infections which have failed to respond to other antibacterials or for patients who cannot be treated with other antibacterials ▶BY MOUTH ▶Adult: 400 mg once daily for 7–21 days Infection ▶BY INTRAVENOUS INFUSION ▶Adult: 400 mg once daily for 7–21 days, to be given over 60 minutes

Source page 615

Contra Indications

Acute myocardial infarction (risk factor for QT interval prolongation). bradycardia (risk factor for QT interval prolongation). congenital long QT syndrome (risk factor for QT interval prolongation). electrolyte disturbances (risk factor for QT interval prolongation). heart failure with reduced left ventricular ejection fraction (risk factor for QT interval prolongation). history of symptomatic arrhythmias (risk factor for QT interval prolongation)

Source page 615

Safety

Extracted information for Moxifloxacin only.

Interactions

→Appendix 1: quinolones

Source page 615

Side Effects

▶Uncommon Angina pectoris. dehydration. gastritis. hyperlipidaemia. malaise. pelvic pain ▶Rare or very rare Concentration impaired. depersonalisation. dysphagia. emotional lability. generalised tonic-clonic seizure. hypertension. hyperuricaemia. memory loss. speech disorder

Source page 615

Breast Feeding

Manufacturer advises avoid—present in milk in animal studies.

Source page 615

Hepatic Impairment

Manufacturer advises avoid in severe impairment or increased transaminases (5 times upper limit of normal).

Source page 615

Dose and formulations

Extracted information for Moxifloxacin only.

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Tablet CAUTIONARY AND ADVISORY LABELS 6, 9 ▶Moxifloxacin (Non-proprietary) Moxifloxacin (as Moxifloxacin hydrochloride) 400 mg Moxifloxacin 400mg tablets | 5 tablet P £11.81 DT = £10.89 ▶Avelox (Bayer Plc) Moxifloxacin (as Moxifloxacin hydrochloride) 400 mg Avelox 400mg tablets | 5 tablet P £12.43 DT = £10.89 Solution for infusion ELECTROLYTES: May contain Sodium ▶Moxifloxacin (Non-proprietary) Moxifloxacin (as Moxifloxacin hydrochloride) 1.6 mg per 1 ml Moxifloxacin 400mg/250ml solution for infusion bottles | 10 bottle P £399.50–£535.40 (Hospital only) ▶Avelox (Bayer Plc) Moxifloxacin (as Moxifloxacin hydrochloride) 1.6 mg per 1 ml Avelox 400mg/250ml solution for infusion bottles | 1 bottle P £39.95 (Hospital only) | 5 bottle P £199.75 (Hospital only) eiiii F 589

Source page 615

Clinical care

Extracted information for Moxifloxacin only.

Patient And Carer Advice

Driving and skilled tasks May impair performance of skilled tasks (e.g. driving).

Source page 615

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

400 mg once daily for 7 days

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 615

Adults

First line only; read the complete Indications and dose section above.

400 mg once daily for 7–14 days

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 615

Adults

First line only; read the complete Indications and dose section above.

400 mg once daily for 7–14 days, to be given

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 615

Adults

First line only; read the complete Indications and dose section above.

400 mg once daily for 5–10 days

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 615

Adults

First line only; read the complete Indications and dose section above.

400 mg once daily for 14 days

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 615

Adults

First line only; read the complete Indications and dose section above.

400 mg once daily for 7–21 days

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 615

Adults

First line only; read the complete Indications and dose section above.

400 mg once daily for 7–21 days, to be given

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 615

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.

Individual generic drug information

moxifloxacin

Reference monograph

Part of registered formulation

MOXIFLOXACIN HYDROCHLORIDE

Reference record: Moxifloxacin
Source: BNF 80 (2020–2021)
Printed source pages: 615
Age groups indexed: 1

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Moxifloxacin only.

Indications And Dose

Source page 615

Contra Indications

Source page 615

Safety

Extracted information for Moxifloxacin only.

Interactions

→Appendix 1: quinolones

Source page 615

Side Effects

Source page 615

Breast Feeding

Manufacturer advises avoid—present in milk in animal studies.

Source page 615

Hepatic Impairment

Manufacturer advises avoid in severe impairment or increased transaminases (5 times upper limit of normal).

Source page 615

Dose and formulations

Extracted information for Moxifloxacin only.

Medicinal Forms

Source page 615

Clinical care

Extracted information for Moxifloxacin only.

Patient And Carer Advice

Driving and skilled tasks May impair performance of skilled tasks (e.g. driving).

Source page 615

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

400 mg once daily for 7 days

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 615

Adults

First line only; read the complete Indications and dose section above.

400 mg once daily for 7–14 days

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 615

Adults

First line only; read the complete Indications and dose section above.

400 mg once daily for 7–14 days, to be given

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 615

Adults

First line only; read the complete Indications and dose section above.

400 mg once daily for 5–10 days

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 615

Adults

First line only; read the complete Indications and dose section above.

400 mg once daily for 14 days

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 615

Adults

First line only; read the complete Indications and dose section above.

400 mg once daily for 7–21 days

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 615

Adults

First line only; read the complete Indications and dose section above.

400 mg once daily for 7–21 days, to be given

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 615

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.