Individual generic drug information

nifedipine

Reference monograph

Part of registered formulation

NIFEDIPINE

Reference record: Nifedipine
Source: BNF 80 (2020–2021)
Printed source pages: 196, 197
Age groups indexed: 1

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Nifedipine only.

Indications And Dose

Cardiovascular system Raynaud’s syndrome ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Adult: Initially 5 mg 3 times a day, then adjusted according to response to 20 mg 3 times a day Angina prophylaxis (not recommended) ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Adult: Initially 5 mg 3 times a day, then adjusted according to response to 20 mg 3 times a day Postponement of premature labour ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Adult: Initially 20 mg, followed by 10–20 mg 3–4 times a day, adjusted according to uterine activity Hiccup in palliative care ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Adult: 10 mg 3 times a day Chronic anal fissure ▶BY RECTUM USING OINTMENT ▶Adult: Apply 2–3 times a day until pain stops. Max. duration of use 8 weeks, apply to anal canal, using 0.2%–0.5% topical preparation ▶BY MOUTH USING MODIFIED-RELEASE MEDICINES ▶Adult: 20 mg twice daily until pain stops. Max. duration of use 8 weeks ADIPINE ® MR Hypertension | Angina prophylaxis ▶BY MOUTH ▶Adult: 10 mg twice daily, adjusted according to response to 40 mg twice daily ADIPINE ® XL Hypertension | Angina prophylaxis ▶BY MOUTH ▶Adult: 30 mg daily, increased if necessary up to 90 mg daily CORACTEN ® SR Hypertension | Angina prophylaxis ▶BY MOUTH ▶Adult: Initially 10 mg twice daily, increased if necessary up to 40 mg twice daily CORACTEN ® XL Hypertension | Angina prophylaxis ▶BY MOUTH ▶Adult: Initially 30 mg daily, increased if necessary up to 90 mg daily FORTIPINE ® LA 40 Hypertension | Angina prophylaxis ▶BY MOUTH ▶Adult: Initially 40 mg once daily, increased if necessary to 80 mg daily in 1–2 divided doses NIFEDIPRESS ® MR Hypertension | Angina prophylaxis ▶BY MOUTH ▶Adult: 10 mg twice daily, adjusted according to response to 40 mg twice daily TENSIPINE ® MR Hypertension | Angina prophylaxis ▶BY MOUTH ▶Adult: Initially 10 mg twice daily, adjusted according to response to 40 mg twice daily VALNI ® XL Severe hypertension | Prophylaxis of angina ▶BY MOUTH ▶Adult: 30 mg once daily, increased if necessary up to 90 mg once daily l UNLICENSED USE ▶With systemic use Not licensed for use in postponing premature labour. g Nifedipine is used for the treatment of chronic anal ﬁssure, l but is not licensed for this indication.

Source page 196

Contra Indications

▶With systemic use Acute attacks of angina. cardiogenic shock. signiﬁcant aortic stenosis. unstable angina. within 1 month of myocardial infarction CONTRA-INDICATIONS, FURTHER INFORMATION Systemic absorption following rectal use is unknown, therefore consider the possibility of contra-indications listed for systemic use.

Source page 196

Cautions

▶With systemic use Diabetes mellitus. elderly. heart failure. ischaemic pain. poor cardiac reserve. severe hypotension. short-acting formulations are not recommended for angina or long-term management of hypertension (their use may be associated with large variations in blood pressure and reﬂex tachycardia). signiﬁcantly impaired left ventricular function (heart failure deterioration observed) CAUTIONS, FURTHER INFORMATION Systemic absorption following rectal use is unknown, therefore consider the possibility of cautions listed for systemic use. ▶Ischaemic pain Manufacturer advises discontinue if ischaemic pain occurs or existing pain worsens shortly after initiating treatment. VALNI ® XL Dose form not appropriate for use where there is a history of oesophageal or gastro-intestinal obstruction, decreased lumen diameter of the gastro- intestinal tract, inﬂammatory bowel disease, or ileostomy after proctocolectomy.

Source page 196

Prescribing And Dispensing Information

Different versions of modiﬁed-release preparations may not have the same clinical effect. To avoid confusion between these different formulations of nifedipine, prescribers should specify the brand to be dispensed. Palliative care For further information on the use of nifedipine in palliative care, see www.medicinescomplete. com/#/content/palliative/nifedipine.

Source page 197

Safety

Extracted information for Nifedipine only.

Interactions

→Appendix 1: calcium channel blockers

Source page 196

Side Effects

▶Common or very common Constipation. malaise. oedema. vasodilation ▶Uncommon Allergic oedema. anxiety. chills. diarrhoea. dry mouth. epistaxis. gastrointestinal discomfort. gastrointestinal disorders. hypotension. joint disorders. laryngeal oedema. migraine. muscle complaints. nasal congestion. pain. sleep disorders. tremor. urinary disorders. vertigo. vision disorders ▶Rare or very rare Appetite decreased. burping. cardiovascular disorder. fever. hyperhidrosis. mood altered. sensation abnormal ▶Frequency not known Agranulocytosis. bezoar. cerebral ischaemia. chest pain. dysphagia. dyspnoea. eye pain. gingival disorder. gynaecomastia (following long term use). hepatic disorders. hyperglycaemia. ischaemic heart disease. leucopenia. myasthenia gravis aggravated. photoallergic reaction. pulmonary oedema. telangiectasia . toxic epidermal necrolysis. weight decreased SIDE-EFFECTS, FURTHER INFORMATION Systemic absorption following rectal use is unknown therefore consider the possibility of side-effects listed for oral use.

Source page 196

Pregnancy

▶With systemic use May inhibit labour; manufacturer advises avoid before week 20, but risk to fetus should be balanced against risk of uncontrolled maternal hypertension. Use only if other treatment options are not indicated or have failed.

Source page 196

Breast Feeding

▶With systemic use Amount too small to be harmful but manufacturers advise avoid.

Source page 196

Hepatic Impairment

▶With oral use For once-daily preparations, manufacturers advise dose form not appropriate (owing to the duration of action of the formulation). Dose adjustments ▶With oral use Manufacturer advises consider dose reduction in severe impairment.

Source pages 196, 197

Dose and formulations

Extracted information for Nifedipine only.

Directions For Administration

FORTIPINE ® LA 40 Take with or just after food, or a meal.

Source page 197

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral suspension, oral drops Modified-release tablet CAUTIONARY AND ADVISORY LABELS 25 ▶Adanif XL (Advanz Pharma) Nifedipine 30 mg Adanif XL 30mg tablets | 28 tablet P £9.70 DT = £4.70 Nifedipine 60 mg Adanif XL 60mg tablets | 28 tablet P £11.20 DT = £7.10 ▶Adipine MR (Chiesi Ltd) Nifedipine 10 mg Adipine MR 10 tablets | 56 tablet P £3.73 DT = £9.23 Nifedipine 20 mg Adipine MR 20 tablets | 56 tablet P £5.21 DT = £10.06 ▶Adipine XL (Chiesi Ltd) Nifedipine 30 mg Adipine XL 30mg tablets | 28 tablet P £4.70 DT = £4.70 Nifedipine 60 mg Adipine XL 60mg tablets | 28 tablet P £7.10 DT = £7.10 ▶Fortipine LA (Advanz Pharma) Nifedipine 40 mg Fortipine LA 40 tablets | 30 tablet P £14.40 DT = £14.40 ▶Nidef (Morningside Healthcare Ltd) Nifedipine 30 mg Nidef 30mg modified-release tablets | 28 tablet P £6.85 DT = £4.70 Nifedipine 60 mg Nidef 60mg modified-release tablets | 28 tablet P £9.03 DT = £7.10 ▶Nifedipress MR (Dexcel-Pharma Ltd) Nifedipine 10 mg Nifedipress MR 10 tablets | 56 tablet P £9.23 DT = £9.23 Nifedipine 20 mg Nifedipress MR 20 tablets | 56 tablet P £10.06 DT = £10.06 ▶Tensipine MR (Genus Pharmaceuticals Ltd) Nifedipine 10 mg Tensipine MR 10 tablets | 56 tablet P £4.30 DT = £9.23 Nifedipine 20 mg Tensipine MR 20 tablets | 56 tablet P £5.49 DT = £10.06 ▶Valni Retard (Tillomed Laboratories Ltd) Nifedipine 20 mg Valni 20 Retard tablets | 56 tablet P £10.06 DT = £10.06 ▶Valni XL (Zentiva) Nifedipine 30 mg Valni XL 30mg tablets | 28 tablet P £6.85 DT = £4.70 Nifedipine 60 mg Valni XL 60mg tablets | 28 tablet P £9.03 DT = £7.10 Modified-release capsule CAUTIONARY AND ADVISORY LABELS 25 ▶Coracten SR (UCB Pharma Ltd) Nifedipine 10 mg Coracten SR 10mg capsules | 60 capsule P £3.90 DT = £3.90 Nifedipine 20 mg Coracten SR 20mg capsules | 60 capsule P £5.41 DT = £5.41 ▶Coracten XL (UCB Pharma Ltd) Nifedipine 30 mg Coracten XL 30mg capsules | 28 capsule P £4.89 DT = £4.89 Nifedipine 60 mg Coracten XL 60mg capsules | 28 capsule P £7.34 DT = £7.34 Oral drops ▶Nifedipin-ratiopharm (Imported (Germany)) Nifedipine 20 mg per 1 ml Nifedipin-ratiopharm 20mg/ml oral drops | 30 ml P s Capsule ▶Nifedipine (Non-proprietary) Nifedipine 5 mg Nifedipine 5mg capsules | 90 capsule P £51.95 DT = £51.95 Nifedipine 10 mg Nifedipine 10mg capsules | 90 capsule P Cardiovascular system £65.63 DT = £65.63 Combinations available: Atenolol with nifedipine, p. 164 eiiii F 168

Source page 197

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

Initially 5 mg 3 times a day, then adjusted

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 196

Adults

First line only; read the complete Indications and dose section above.

Initially 5 mg 3 times a day, then adjusted

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 196

Adults

First line only; read the complete Indications and dose section above.

Initially 20 mg, followed by 10–20 mg 3–4 times

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 196

Adults

First line only; read the complete Indications and dose section above.

10 mg 3 times a day

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 196

Adults

First line only; read the complete Indications and dose section above.

Apply 2–3 times a day until pain stops. Max.

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 196

Adults

First line only; read the complete Indications and dose section above.

20 mg twice daily until pain stops. Max. duration

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 196

Adults

First line only; read the complete Indications and dose section above.

10 mg twice daily, adjusted according to

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 196

Adults

First line only; read the complete Indications and dose section above.

30 mg daily, increased if necessary up to 90 mg

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 196

Adults

First line only; read the complete Indications and dose section above.

Initially 10 mg twice daily, increased if necessary

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 196

Adults

First line only; read the complete Indications and dose section above.

Initially 30 mg daily, increased if necessary up to

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 196

Adults

First line only; read the complete Indications and dose section above.

Initially 40 mg once daily, increased if necessary

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 196

Adults

First line only; read the complete Indications and dose section above.

10 mg twice daily, adjusted according to

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 196

Adults

First line only; read the complete Indications and dose section above.

Initially 10 mg twice daily, adjusted according to

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 196

Adults

First line only; read the complete Indications and dose section above.

30 mg once daily, increased if necessary up to

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 196

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.

Individual generic drug information

nifedipine

Reference monograph

Part of registered formulation

NIFEDIPINE

Reference record: Nifedipine
Source: BNF 80 (2020–2021)
Printed source pages: 196, 197
Age groups indexed: 1

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Nifedipine only.

Indications And Dose

Source page 196

Contra Indications

Source page 196

Cautions

Source page 196

Prescribing And Dispensing Information

Source page 197

Safety

Extracted information for Nifedipine only.

Interactions

→Appendix 1: calcium channel blockers

Source page 196

Side Effects

Source page 196

Pregnancy

Source page 196

Breast Feeding

▶With systemic use Amount too small to be harmful but manufacturers advise avoid.

Source page 196

Hepatic Impairment

Source pages 196, 197

Dose and formulations

Extracted information for Nifedipine only.

Directions For Administration

FORTIPINE ® LA 40 Take with or just after food, or a meal.

Source page 197

Medicinal Forms

Source page 197

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

Initially 5 mg 3 times a day, then adjusted

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 196

Adults

First line only; read the complete Indications and dose section above.

Initially 5 mg 3 times a day, then adjusted

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 196

Adults

First line only; read the complete Indications and dose section above.

Initially 20 mg, followed by 10–20 mg 3–4 times

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 196

Adults

First line only; read the complete Indications and dose section above.

10 mg 3 times a day

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 196

Adults

First line only; read the complete Indications and dose section above.

Apply 2–3 times a day until pain stops. Max.

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 196

Adults

First line only; read the complete Indications and dose section above.

20 mg twice daily until pain stops. Max. duration

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 196

Adults

First line only; read the complete Indications and dose section above.

10 mg twice daily, adjusted according to

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 196

Adults

First line only; read the complete Indications and dose section above.

30 mg daily, increased if necessary up to 90 mg

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 196

Adults

First line only; read the complete Indications and dose section above.

Initially 10 mg twice daily, increased if necessary

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 196

Adults

First line only; read the complete Indications and dose section above.

Initially 30 mg daily, increased if necessary up to

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 196

Adults

First line only; read the complete Indications and dose section above.

Initially 40 mg once daily, increased if necessary

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 196

Adults

First line only; read the complete Indications and dose section above.

10 mg twice daily, adjusted according to

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 196

Adults

First line only; read the complete Indications and dose section above.

Initially 10 mg twice daily, adjusted according to

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 196

Adults

First line only; read the complete Indications and dose section above.

30 mg once daily, increased if necessary up to

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 196

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.