Individual generic drug information

ofloxacin

Reference monograph

Part of registered formulation

OFLOXACIN

Reference record: Ofloxacin
Source: BNF 80 (2020–2021)
Printed source pages: 615, 616
Age groups indexed: 1

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Ofloxacin only.

Indications And Dose

Urinary-tract infections ▶BY MOUTH ▶Adult: 200–400 mg daily, preferably taken in the morning; increased if necessary to 400 mg twice daily, continued → in upper urinary tract infections Complicated urinary-tract infection ▶BY INTRAVENOUS INFUSION ▶Adult: 200 mg daily, increased if necessary to 400 mg twice daily, dose increased for severe or complicated infections, to be given over at least 30 minutes for each 200 mg Prostatitis ▶BY MOUTH Infection ▶Adult: 200 mg twice daily for 14 or 28 days based on clinical assessment Lower respiratory-tract infections ▶BY MOUTH ▶Adult: 400 mg daily, dose preferably taken in the morning, then increased if necessary to 400 mg twice daily ▶BY INTRAVENOUS INFUSION ▶Adult: 200 mg twice daily, increased to 400 mg twice daily, dose to be increased for severe or complicated infections, to be given over at least 30 minutes for each 200 mg Skin and soft-tissue infections ▶BY MOUTH ▶Adult: 400 mg twice daily ▶BY INTRAVENOUS INFUSION ▶Adult: 400 mg twice daily, to be given over at least 30 minutes for each 200 mg Uncomplicated gonorrhoea ▶BY MOUTH ▶Adult: 400 mg as a single dose Uncomplicated genital chlamydial infection | Non- gonococcal urethritis ▶BY MOUTH ▶Adult: 400 mg daily for 7 days, dose may be taken as a single daily dose or in divided doses Pelvic inflammatory disease ▶BY MOUTH ▶Adult: 400 mg twice daily for 14 days

Source pages 615, 616

Cautions

Acute myocardial infarction (risk factor for QT interval prolongation). bradycardia (risk factor for QT interval prolongation). congenital long QT syndrome (risk factor for QT interval prolongation). electrolyte disturbances (risk factor for QT interval prolongation). heart failure with reduced left ventricular ejection fraction (risk factor for QT interval prolongation). history of symptomatic arrhythmias (risk factor for QT interval prolongation)

Source page 616

Safety

Extracted information for Ofloxacin only.

Interactions

→Appendix 1: quinolones

Source page 616

Side Effects

▶Rare or very rare Enterocolitis. enterocolitis haemorrhagic ▶Frequency not known Bone marrow failure. myopathy. nephritis acute interstitial

Source page 616

Breast Feeding

Amount probably too small to be harmful but manufacturer advises avoid.

Source page 616

Hepatic Impairment

Manufacturer advises caution. Dose adjustments Manufacturer advises maximum 400 mg daily in hepatic failure (risk of decreased elimination).

Source page 616

Renal Impairment

Dose adjustments Usual initial dose, then use half normal dose if eGFR 20–50 mL/minute/1.73 m2; 100 mg every 24 hours if eGFR less than 20 mL/minute/1.73 m2

Source page 616

Dose and formulations

Extracted information for Ofloxacin only.

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral suspension, oral solution Tablet CAUTIONARY AND ADVISORY LABELS 6, 9, 11 ▶Ofloxacin (Non-proprietary) Ofloxacin 200 mg Ofloxacin 200mg tablets | 10 tablet P £9.00 DT = £8.39 Ofloxacin 400 mg Ofloxacin 400mg tablets | 5 tablet P £13.32 DT = £13.30 | 10 tablet P £4.59–£27.27 ▶Tarivid (Sanofi) Ofloxacin 400 mg Tarivid 400mg tablets | 10 tablet P £14.99 Solution for infusion ▶Tarivid (Sanofi) Ofloxacin (as Ofloxacin hydrochloride) 2 mg per 1 ml Tarivid 200mg/100ml solution for infusion bottles | 1 bottle P £16.16 ANTIBACTERIALS › SULFONAMIDES

Source page 616

Clinical care

Extracted information for Ofloxacin only.

Patient And Carer Advice

Driving and skilled tasks May affect performance of skilled tasks (e.g. driving); effects enhanced by alcohol.

Source page 616

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

200–400 mg daily, preferably taken in the

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 615

Adults

First line only; read the complete Indications and dose section above.

200 mg daily, increased if necessary to 400 mg

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 616

Adults

First line only; read the complete Indications and dose section above.

200 mg twice daily for 14 or 28 days based on

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 616

Adults

First line only; read the complete Indications and dose section above.

400 mg daily, dose preferably taken in the

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 616

Adults

First line only; read the complete Indications and dose section above.

200 mg twice daily, increased to 400 mg twice

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 616

Adults

First line only; read the complete Indications and dose section above.

400 mg twice daily

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 616

Adults

First line only; read the complete Indications and dose section above.

400 mg twice daily, to be given over at least

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 616

Adults

First line only; read the complete Indications and dose section above.

400 mg as a single dose

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 616

Adults

First line only; read the complete Indications and dose section above.

400 mg daily for 7 days, dose may be taken as a

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 616

Adults

First line only; read the complete Indications and dose section above.

400 mg twice daily for 14 days

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 616

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.

Individual generic drug information

ofloxacin

Reference monograph

Part of registered formulation

OFLOXACIN

Reference record: Ofloxacin
Source: BNF 80 (2020–2021)
Printed source pages: 615, 616
Age groups indexed: 1

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Ofloxacin only.

Indications And Dose

Source pages 615, 616

Cautions

Source page 616

Safety

Extracted information for Ofloxacin only.

Interactions

→Appendix 1: quinolones

Source page 616

Side Effects

▶Rare or very rare Enterocolitis. enterocolitis haemorrhagic ▶Frequency not known Bone marrow failure. myopathy. nephritis acute interstitial

Source page 616

Breast Feeding

Amount probably too small to be harmful but manufacturer advises avoid.

Source page 616

Hepatic Impairment

Manufacturer advises caution. Dose adjustments Manufacturer advises maximum 400 mg daily in hepatic failure (risk of decreased elimination).

Source page 616

Renal Impairment

Dose adjustments Usual initial dose, then use half normal dose if eGFR 20–50 mL/minute/1.73 m2; 100 mg every 24 hours if eGFR less than 20 mL/minute/1.73 m2

Source page 616

Dose and formulations

Extracted information for Ofloxacin only.

Medicinal Forms

Source page 616

Clinical care

Extracted information for Ofloxacin only.

Patient And Carer Advice

Driving and skilled tasks May affect performance of skilled tasks (e.g. driving); effects enhanced by alcohol.

Source page 616

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

200–400 mg daily, preferably taken in the

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 615

Adults

First line only; read the complete Indications and dose section above.

200 mg daily, increased if necessary to 400 mg

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 616

Adults

First line only; read the complete Indications and dose section above.

200 mg twice daily for 14 or 28 days based on

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 616

Adults

First line only; read the complete Indications and dose section above.

400 mg daily, dose preferably taken in the

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 616

Adults

First line only; read the complete Indications and dose section above.

200 mg twice daily, increased to 400 mg twice

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 616

Adults

First line only; read the complete Indications and dose section above.

400 mg twice daily

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 616

Adults

First line only; read the complete Indications and dose section above.

400 mg twice daily, to be given over at least

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 616

Adults

First line only; read the complete Indications and dose section above.

400 mg as a single dose

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 616

Adults

First line only; read the complete Indications and dose section above.

400 mg daily for 7 days, dose may be taken as a

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 616

Adults

First line only; read the complete Indications and dose section above.

400 mg twice daily for 14 days

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 616

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.