Therapeutic Action
Antiemetic (serotonin 5-HT3 receptor antagonist)
Source page 466
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Individual generic drug information
Extracted information for ONDANSETRON only.
Antiemetic (serotonin 5-HT3 receptor antagonist)
Source page 466
Prevention of post-operative nausea and vomiting in children Treatment of post-operative nausea and vomiting
Source page 466
Extracted information for ONDANSETRON only.
Do not administer to children less than 1 month of age. Administer with caution and monitor use in patients with congenital long QT syndrome, cardiac insufficiency and bradycardia. Reduce the dose in patients with hepatic failure (max. 8 mg daily). May cause: headache, sensation of flushing or warmth, hiccups, constipation, heart rhythm disorders, QT interval prolongation, extrapyramidal reactions, seizures, cutaneous allergic reactions (Lyell’s and Stevens-johnson syndromes). Avoid or monitor combination with: drugs that prolong the QT interval: amiodarone, bedaquilline, chloroquine, co-artemether, erythromycin, fluconazole, haloperidol, moxifloxacin, mefloquine, pentamidine, quinine, etc.; serotonergics: fluoxetine, paroxetine, tricyclic antidepressants, etc.; enzyme inducers: rifampicin, rifabutin, nevirapine, ritonavir, phenobarbital, phenytoin, carbamazepine, griseofulvin, etc. (efficacy of ondansetron reduced); tramadol (antalgic effect reduced). Pregnancy: avoid during the first trimester; not recommended for nausea and vomiting of pregnancy Breast-feeding: not recommended
Source pages 466, 467
Extracted information for ONDANSETRON only.
4 mg ampoule (2 mg/ml, 2 ml) for slow IV injection (3 to 5 minutes)
Source page 466
Prevention of post-operative nausea and vomiting Child over 1 month: 0.1 mg/kg at the end of surgery (max. 4 mg per injection) Treatment of nausea and vomiting Child over 1 month: No prophylactic dose of ondansetron received: 0.1 mg/kg every 8 hours if necessary Prophylactic dose of ondansetron received and late postoperative vomiting (≥ 6 hours after surgery): 0.1 mg/kg every 6 hours if necessary Do not exceed 4 mg per injection and 3 injections per 24 hours. Adult: 4 mg every 8 hours if necessary (max. 3 injections per 24 hours)
Source page 466
Extracted information for ONDANSETRON only.
– Below 25 °C
Source page 467
Filter the extracted dose blocks for this individual drug.
4 mg every 8 hours if necessary (max. 3 injections per 24 hours)
Candidate age grouping · source page 466