Indications And Dose
Nocturnal leg cramps ▶BY MOUTH ▶Adult: 200–300 mg once daily, to be taken at bedtime Non-falciparum malaria ▶BY INTRAVENOUS INFUSION ▶Adult: 10 mg/kg every 8 hours (max. per dose 700 mg), infused over 4 hours, given if patient is unable to take oral therapy. Change to oral chloroquine as soon as the patient’s condition permits, reduce dose to 5–7 mg/kg if parenteral treatment is required for more than 48 hours Falciparum malaria ▶BY MOUTH ▶Child: 10 mg/kg every 8 hours (max. per dose 600 mg) for 7 days, to be given together with or followed by either doxycycline (in children over 12 years), or clindamycin ▶Adult: 600 mg every 8 hours for 5–7 days, to be given together with or followed by either doxycycline or clindamycin ▶BY INTRAVENOUS INFUSION ▶Adult: Loading dose 20 mg/kg (max. per dose 1.4 g), infused over 4 hours, the loading dose of 20 mg/kg should not be used if the patient has received quinine or mefloquine during the previous 12 hours, then maintenance 10 mg/kg every 8 hours (max. per dose 700 mg) until patient can swallow tablets to complete the 7-day course, maintenance dose to be given 8 hours after the start of the loading dose and infused over 4 hours, to be given together with or followed by either doxycycline or clindamycin, reduce maintenance dose to 5–7 mg/kg if parenteral treatment is required for more than 48 hours Falciparum malaria (in intensive care unit) ▶BY INTRAVENOUS INFUSION ▶Adult: Loading dose 7 mg/kg, infused over 30 minutes, followed immediately by 10 mg/kg, infused over 4 hours, then maintenance 10 mg/kg every 8 hours (max. per dose 700 mg) until patient can swallow tablets to complete the 7-day course, maintenance dose to be given 8 hours after the start of the loading dose and infused over 4 hours, to be given together with or followed by either doxycycline or clindamycin, reduce maintenance dose to 5–7 mg/kg if parenteral treatment is required for more than 48 hours DOSE EQUIVALENCE AND CONVERSION ▶When using quinine for malaria, doses are valid for quinine hydrochloride, dihydrochloride, and sulfate; they are not valid for quinine bisulfate which contains a correspondingly smaller amount of quinine. ▶Quinine (anhydrous base) 100 mg = quinine bisulfate 169 mg; quinine dihydrochloride 122 mg; quinine hydrochloride 122 mg; and quinine sulfate 121 mg. Infection Quinine bisulfate 300 mg tablets are available but provide less quinine than 300 mg of the dihydrochloride, hydrochloride, or sulfate. l UNLICENSED USE Injection not licensed.
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